Lipid kinetic alterations in tumor-bearing rats: Reversal by tumor excision Conference Paper
| Authors: | Younes, R. N.; Vydelingum, N. A.; Noguchi, Y.; Brennan, M. F. |
| Title: | Lipid kinetic alterations in tumor-bearing rats: Reversal by tumor excision |
| Conference Title: | Annual Meeting of the Association for Academic Surgery |
| Abstract: | Cancer cachexia is frequently accompanied by hyperlipidemia. To identify the mechanisms underlying this alteration in lipid metabolism, free fatty acid (FFA) and very low density lipoprotein-associated triacylglycerol (VLDL-TG) kinetics were determined in tumor-bearing (subcutaneously implanted methylcholanthrene-induced sarcoma) Fischer 344 rats. The animals were studied after chronic vascular catheterization, in an unanesthetized, undisturbed state, after 24 hr of fasting. They were separated into three groups: control (n = 5), tumor-bearing (n = 5, tumor burden = 10% body weight), and 7 days after tumor excision (n = 5). VLDL-TG and FFA kinetics were assessed by a constant infusion of [3H]palmitate-labeled VLDL-TG and [14C]palmitate bound to albumin, respectively. FFA rate of appearance (FFA-Ra) and clearance (FFA-Cl) and VLDL-TG rate of appearance (VLDL-TG-Ra) and clearance (VLDL-TG-Cl) were determined at steady state. We observed that the tumor-bearing rats had significantly increased FFA-Ra and VLDL-TG-Ra, decreased VLDL-CL, and maintained FFA-Cl, when compared to control. These alterations returned to normal levels after tumor excision. The results suggest that the hyperlipidemia observed in tumor-bearing rats is due to elevated lipolysis rate, maintained rate of plasma FFA clearance, increased triacylglycerol production and VLDL secretion by the liver, and decreased VLDL-TG clearance from plasma. These alterations were reversed 7 days following tumor excision. © 1990. |
| Keywords: | postoperative period; nonhuman; conference paper; animal; animal experiment; kinetics; rat; lipids; rats; cachexia; hyperlipidemia; triglycerides; rats, inbred f344; sarcoma, experimental; fatty acids, nonesterified; osmolar concentration; male; priority journal; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; lipoproteins, vldl |
| Journal Title | Journal of Surgical Research |
| Volume: | 48 |
| Issue: | 4 |
| Conference Dates: | 1989 Nov 15-18 |
| Conference Location: | Louisville, KY |
| ISBN: | 0022-4804 |
| Publisher: | Academic Press Inc., Elsevier Science |
| Date Published: | 1990-04-01 |
| Start Page: | 324 |
| End Page: | 328 |
| Language: | English |
| DOI: | 10.1016/0022-4804(90)90067-c |
| PUBMED: | 2338818 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 27 January 2020 -- Source: Scopus |
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