Anti-epidermal growth factor receptor monoclonal antibodies as potential anti-cancer agents Journal Article
| Author: | Mendelsohn, J. |
| Article Title: | Anti-epidermal growth factor receptor monoclonal antibodies as potential anti-cancer agents |
| Abstract: | The EGF receptor is a potential target for antitumor therapy, because it is expressed at high levels on many human tumor cells and appears to be involved in autocrine stimulation of cell growth in a number of experimental studies. Anti-EGF receptor MAbs, which block ligand binding, can prevent the growth in culture of cells that are stimulated by EGF or TGF-α. Growth of human tumor xenografts bearing high levels of EGF receptors is also inhibited. A Phase I trial in patients with squamous cell carcinoma of the lung has demonstrated the capacity of a single dose of 120 mg anti-EGF receptor MAb to localize in such tumors and to achieve saturating concentrations in the blood for more than 3 days, without causing toxicity. © 1990. |
| Keywords: | epidermal growth factor; controlled study; human cell; carcinoma, squamous cell; nonhuman; antineoplastic agents; conference paper; mouse; lung neoplasms; animal experiment; animal model; lung cancer; receptor, epidermal growth factor; tumor cells, cultured; animalia; antibodies, monoclonal; transplantation, heterologous; tumor growth; transforming growth factor alpha; human; priority journal |
| Journal Title: | Journal of Steroid Biochemistry and Molecular Biology |
| Volume: | 37 |
| Issue: | 6 |
| ISSN: | 0960-0760 |
| Publisher: | Pergamon-Elsevier Science Ltd |
| Date Published: | 1990-12-20 |
| Start Page: | 889 |
| End Page: | 892 |
| Language: | English |
| DOI: | 10.1016/0960-0760(90)90438-q |
| PUBMED: | 2285602 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 27 January 2020 -- Source: Scopus |
