A rapid assay of suramin in plasma Journal Article
| Authors: | Tong, W. P.; Scher, H. I.; Petrylak, D. P.; Dnistrian, A.; Curley, T.; Vasquez, J. |
| Article Title: | A rapid assay of suramin in plasma |
| Abstract: | The polysulfonated napthylurea suramin is currently undergoing extensive clinical trials. A narrow therapeutic window requires frequent dose adjustment to minimize toxicity. A simple, rapid and reproducible assay was developed for measuring suramin levels in plasma. Plasma samples are injected directly onto the column and eluted isocratically with acetonitrile and an ion pairing reagent. Retention time is approximately two minutes, recovery greater than 95% throughout the range of 50–300 ug/ml, with sensitivities to concentrations of 5 ug. A small sample size (0.5 ul) gave similar results allowing assays of finger-stick samples. Equal accuracy was. © 1990, Taylor & Francis Group, LLC. All rights reserved. |
| Keywords: | human tissue; drug determination; suramin; sampling; human experiment; blood level; human; article |
| Journal Title: | Journal of Liquid Chromatography |
| Volume: | 13 |
| Issue: | 11 |
| ISSN: | 0148-3919 |
| Publisher: | Taylor & Francis Inc. |
| Date Published: | 1990-01-01 |
| Start Page: | 2269 |
| End Page: | 2284 |
| Language: | English |
| DOI: | 10.1080/01483919008049030 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 27 January 2020 -- Source: Scopus |
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