Prospective computer-assisted voice analysis for patients with early stage glottic cancer: A preliminary report of the functional result of laryngeal irradiation Journal Article

  

Authors:	Harrison, L. B.; Solomon, B.; Miller, S.; Fass, D. E.; Armstrong, J.; Sessions, R. B.
Article Title:	Prospective computer-assisted voice analysis for patients with early stage glottic cancer: A preliminary report of the functional result of laryngeal irradiation
Abstract:	In January 1987 we began a prospective study aimed at evaluating objective parameters of vocal function for all patients treated with RT for early glottic cancer. All patients underwent vocal analysis using a voice analyzer interfaced with a computer. This allowed for the determination of percent voicing (%V) (normal = presence of phonation = 90-100%V). Other parameters such as breathiness (air turbulence or hoarseness) and strain (vocal cord tension) were also measured. Patients were recorded before RT, weekly during RT, and at set intervals after RT. There have been 25 patients studied. Eighteen (18) are evaluable at 9 months after treatment. All patients were male and ranged from 45-84 years old. Fourteen (14) had T1 lesions and received 66 GY/33 fractions to their larynx and 4 had T2 tumors and received 66-70 Gy/33-35 fractions. To date, all patients are locally controlled. Three distinct patterns of %V changes have been encountered. However, all patients demonstrated normal phonation pattern by 3 months after RT, and this is sustained at 9 months follow-up. In addition, 94% of patients have had significant decrease in breathiness after RT, which objectively documents diminished hoarseness. In 83%, breathiness is normal after RT. Most patients have had increased strain after RT, which documents increased vocal cord tension. However, strain remained within normal limits in 89%. Our preliminary analysis suggests that the majority of patients irradiated for early glottic cancer demonstrate a decrease in breathiness and an increase in strain after RT, and enjoy a resultant voice that has normal phonation maintained at 9 months after RT. Our data also demonstrate three distinct phonation patterns. Further follow-up will allow us to determine the prognostic significance, if any, of these patterns, and to continue to follow objective vocal parameters on larger numbers of patient. © 1990.
Keywords:	adult; aged; aged, 80 and over; larynx carcinoma; laryngeal neoplasms; conference paper; methodology; prospective studies; radiotherapy; diagnosis; voice; larynx; phonation; voice quality; computer analysis; middle age; computer systems; human; male; female; priority journal; vocal cord cancer; voice analysis
Journal Title:	International Journal of Radiation Oncology, Biology, Physics
Volume:	19
Issue:	1
ISSN:	0360-3016
Publisher:	Elsevier Inc.
Date Published:	1990-07-01
Start Page:	123
End Page:	127
Language:	English
DOI:	10.1016/0360-3016(90)90144-9
PUBMED:	2380077
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025333110&doi=10.1016%2f0360-3016%2890%2990144-9&partnerID=40&md5=fd0e944b0bf0ad81b8631acd4f475577
Notes:	Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/159358