Molecular characteristics of tumor antigens Journal Article
| Author: | Lloyd, K. O. |
| Article Title: | Molecular characteristics of tumor antigens |
| Abstract: | Tumor antigens have been detected using a variety of approaches, including transplantation (in animal studies), in vitro cell-mediated cytotoxicity assays, the analysis of serum antibodies, and the derivation of human and mouse monoclonal antibodies. The antigens detected have included cell-surface glycoproteins, proteoglycans, mucins, and glycolipids. Some of these structures can be recognized by the host as foreign and result in the development of antitumor responses. Tumor-associated carbohydrate specificities are very common, but none of them are completely tumor specific. No single type of antigenic change, which would indicate a common mechanism for induction, has been associated with malignancy. On the other hand, it is interesting that some antigens, e.g., gp95-p97, and some mucins and gangliosides have been detected as tumor antigens by more than one experimental approach. |
| Keywords: | review; nonhuman; transplantation; tumor antigen; monoclonal antibody; immunoassay; glycoprotein; human |
| Journal Title: | Immunology and Allergy Clinics of North America |
| Volume: | 10 |
| Issue: | 4 |
| ISSN: | 0889-8561 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1990-11-01 |
| Start Page: | 765 |
| End Page: | 779 |
| Language: | English |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
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