Comparison of anatomical location of squamous cell carcinoma within the oral cavity and oropharynx with the incidence of in vitro hyperdiploidy Journal Article
| Authors: | Danes, B. S.; De Angelis, P.; Traganos, F.; Ringborg, U.; Nielsen, L. H.; Melamed, M. R. |
| Article Title: | Comparison of anatomical location of squamous cell carcinoma within the oral cavity and oropharynx with the incidence of in vitro hyperdiploidy |
| Abstract: | The anatomical location of the squamous cell carcinoma (SCCA) within the oral cavity and oropharynx influenced the association of SCCA with the biomarker in vitro hyperdiploidy in human dermal fibroblast cultures (IVH). There was a strong association of IVH with the occurrence of SCCA in the anterior 2/3 of the tongue, floor of the mouth and lower alveolar ridge of the oral cavity and in the base of the tongue and pharyngeal wall of the oropharynx. There was a lower association of SCCA with IVH in the tonsillar region of the oropharynx. IVH showed no association with SCCA located in other anatomical parts of the oral region. The patient group whose diagnosis of SCCA in the anterior 2/3 of the tongue occurred prior to the age of 50 years were invariably IVH‐, whereas those diagnosed after the age of 50 years were IVH+, providing evidence for heterogeneity. There was no such correlation of biomarker subgrouping with age of diagnosis demonstrated for SCCA at any other anatomical location within the oral cavity or oropharynx. Copyright © 1990, Wiley Blackwell. All rights reserved |
| Keywords: | adult; aged; aged, 80 and over; human cell; major clinical study; case-control studies; squamous cell carcinoma; carcinoma, squamous cell; comparative study; cytology; cell line; cell culture; fibroblasts; aneuploidy; mouth neoplasms; fibroblast culture; diploidy; oropharyngeal neoplasms; mouth cavity; oropharynx; middle age; pharyngeal neoplasms; chromosome number; numerical chromosome aberration; human; male; female; priority journal; article; support, non-u.s. gov't; human dermal fibroblast; in vitro biomarker; in vitro hyperdiploidy (ivh); squamous cell carcinoma (scca) within the oral region |
| Journal Title: | Clinical Genetics |
| Volume: | 37 |
| Issue: | 3 |
| ISSN: | 0009-9163 |
| Publisher: | Wiley Blackwell |
| Date Published: | 1990-03-01 |
| Start Page: | 188 |
| End Page: | 193 |
| Language: | English |
| DOI: | 10.1111/j.1399-0004.1990.tb03501.x |
| PUBMED: | 2323088 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
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