Cytokine networks involved in the regulation of haemopoietic stem cell proliferation and differentiation Conference Paper

  

Authors:	Moore, M. A. S.; Muench, M. O.; Warren, D. J.; Laver, J.
Title:	Cytokine networks involved in the regulation of haemopoietic stem cell proliferation and differentiation
Conference Title:	Symposium on Molecular Control of Haemopoiesis
Abstract:	Additive and synergistic interactions between haemopoietic growth factors and cytokines can be demonstrated in vitro in clonogenic and suspension cultures of murine and human bone marrow. Purification of early stem cells by combinations of purging with cytotoxic agents (5-fluorouracil, 4-hydroperoxy-cyclophosphamide) and selection with monoclonal antibodies for CD34+, CD33- cells permits analysis of factor interactions at the level of the primitive pluripotential stem cell. Interactions between interleukins, tumour necrosis factor and the colony-stimulating factors can be monitored. In vivo, IL-1 alone, or in combination with G-CSF produces accelerated reconstitution of haemopoiesis after chemotherapy, irradiation and bone marrow transplantation in murine and primate systems. IL-1 elicits cytokine cascades that may have positive or negative actions on lymphohaemopoiesis. Induction of products of the cyclooxygenase and lipooxygenase pathways, as well as tumour necrosis factor and TGF-beta, modulate haemopoiesis.
Keywords:	review; mouse; animal; cytology; animals; mice; bone marrow cells; cells, cultured; cell division; cell differentiation; drug effect; physiology; cytokine; cytokines; cell culture; hematopoietic stem cells; hematopoiesis; bone marrow cell; hematopoietic stem cell; biological factor; biological factors; humans; human
Journal Title	Ciba Foundation Symposia
Volume:	148
Conference Dates:	1989 May 2-4
Conference Location:	London, United Kingdom
ISBN:	0300-5208
Publisher:	John Wiley & Sons
Date Published:	1990-01-01
Start Page:	43
End Page:	58; discussion 58-61
Language:	English
PUBMED:	2180648
PROVIDER:	scopus
DOI:	10.1002/9780470513880.ch4
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025154395&partnerID=40&md5=078f8c5e67ac4f71e29e991233ac4fcd
Notes:	ISBN: 0-471-92561-6 -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/159229