Expression of mitochondrial cytochrome c oxidase in human colonic cell differentiation, transformation, and risk for colonic cancer Journal Article
| Authors: | Heerdt, B. G.; Halsey, H. K.; Lipkin, M.; Augenlicht, L. H. |
| Article Title: | Expression of mitochondrial cytochrome c oxidase in human colonic cell differentiation, transformation, and risk for colonic cancer |
| Abstract: | In a panel of eight cloned complementary DNA sequences whose level of expression characterize colon cells as transformed in vivo and in vitro, one which may also serve as a marker of risk in familial polyposis and familial colon cancer flat mucosa has been identified as mitochondrial cytochrome c oxidase subunit 3. Mean level of expression of cytochrome c oxidase subunit 3 decreases progressively in colon adenomas and carcinomas relative to normal mucosa in vivo, and returns to higher levels present in biopsies of normal mucosa when the HT29 human colonic adenocarcinoma cell line is induced to differentiate with sodium butyrate. Quantitation of cytochrome c oxidase subunit 3 DNA by dot blots indicated that these changes in expression were not associated with alterations in the number of mitochondrial genomes. © 1990, American Association for Cancer Research. All rights reserved. |
| Keywords: | human cell; cancer risk; heredity; gene expression; colonic neoplasms; cell differentiation; biopsy; cell transformation, neoplastic; dna; molecular sequence data; cell transformation; dna, neoplasm; base sequence; colon carcinoma; mitochondria; colon; complementary dna; cytochrome c oxidase; adenomatous polyposis coli; familial colon polyposis; human; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; cytochrome-c oxidase |
| Journal Title: | Cancer Research |
| Volume: | 50 |
| Issue: | 5 |
| ISSN: | 0008-5472 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 1990-03-01 |
| Start Page: | 1596 |
| End Page: | 1600 |
| Language: | English |
| PUBMED: | 2154329 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 27 January 2020 -- Source: Scopus |
