Injury induced by fatty acids or bile acid in isolated human colonocytes prevented by calcium Journal Article
| Authors: | Buset, M.; Galand, P.; Lipkin, M.; Winawer, S.; Friedman, E. |
| Article Title: | Injury induced by fatty acids or bile acid in isolated human colonocytes prevented by calcium |
| Abstract: | Measurement of the modulation of the growth fraction of isolated normal colonocytes from adult subjects in primary monolayer culture was used as a sensitive quantitative assay to evaluate toxic effects of several endogenous compounds found within the colon. This assay was used to study the role of CaCl2 in blocking cell injury. When added simultaneously with the injurious agent, 5-10 mM CaCl2 blocked the toxicity of physiological concentrations of deoxycholic acid, oleic acid, palmitic acid and lineoleic acid. © 1990. |
| Keywords: | human cell; cells, cultured; cell division; calcium; cell culture; cell damage; epithelium cell; fatty acids; radioisotope; fatty acid; colon; prevention; colon mucosa; linoleic acid; oleic acids; intestinal mucosa; oleic acid; palmitic acid; fatty acids, nonesterified; deoxycholic acid; bile acid; palmitic acids; human; priority journal; article; support, non-u.s. gov't; linoleic acids; colonic epithelium; bile acids; calcium chloride |
| Journal Title: | Cancer Letters |
| Volume: | 50 |
| Issue: | 3 |
| ISSN: | 0304-3835 |
| Publisher: | Elsevier Ireland Ltd. |
| Date Published: | 1990-04-30 |
| Start Page: | 221 |
| End Page: | 226 |
| Language: | English |
| DOI: | 10.1016/0304-3835(90)90269-4 |
| PUBMED: | 2322935 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 27 January 2020 -- Source: Scopus |
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