Blockade of morphine analgesia by both pertussis and cholera toxins in the periaqueductal gray and locus coeruleus Journal Article

  


Authors: Bodnar, R. J.; Paul, D.; Rosenblum, M.; Liu, L.; Pasternak, G. W.
Article Title: Blockade of morphine analgesia by both pertussis and cholera toxins in the periaqueductal gray and locus coeruleus
Abstract: Rats demonstrating analgesia following microinjection of morphine into the periaqueductal gray (PAG) or locus coeruleus (LC) were injected with either pertussis toxin, cholera toxin or saline into the same brain region. Both pertussis and cholera toxin blocked the analgesic effect of morphine at both injection sites for up to 7 days after toxin treatment. These results indicate that morphine analgesia is a complex response involving systems dependent upon Gs as well as Gi of Go proteins. © 1990.
Keywords: aged; nonhuman; animal; animal experiment; time factors; kinetics; locus ceruleus; rat; rats; mesencephalon; morphine; analgesia; microinjections; pertussis toxin; g-protein; morphine analgesia; rats, inbred strains; periaqueductal gray matter; locus coeruleus; periaqueductal gray; male; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; cholera toxin; virulence factors, bordetella
Journal Title: Brain Research
Volume: 529
Issue: 1-2
ISSN: 0006-8993
Publisher: Elsevier Science, Inc.  
Date Published: 1990-10-08
Start Page: 324
End Page: 328
Language: English
DOI: 10.1016/0006-8993(90)90845-3
PUBMED: 2282501
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025110028&doi=10.1016%2f0006-8993%2890%2990845-3&partnerID=40&md5=4953982416d86c4ffc5d0862edc17012
Notes: Article -- Source: Scopus
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MSK Authors
  1. Marc Rosenblum
    424 Rosenblum
  2. Gavril W Pasternak
    414 Pasternak
  3. Dennis J. Paul
    17 Paul
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