A phase I trial of preoperative radiation, proctectomy, and endoanal reconstruction Journal Article
| Authors: | Cohen, A. M.; Minsky, B. D. |
| Article Title: | A phase I trial of preoperative radiation, proctectomy, and endoanal reconstruction |
| Abstract: | • The purpose of this study was to explore the feasibility of sphincter preservation in abdominoperineal resection candidates by combining high-dose preoperative radiation therapy with restorative proctectomy through an endoanal anastomosis. Radiation to the pelvis was given using a three- or four-field technique to 4680 cGy (180 cGy/d) with portals from the top of S1 to 2 cm below the anus. The tumor bed received an additional 360-cGy boost. Four to 6 weeks after radiation therapy was completed, the patients underwent radical surgery. Phase I results for 14 patients are presented. All surgical specimens had negative distal and lateral margins. Surgical complications included one small-bowel obstruction requiring reoperation at 3 weeks, one pulmonary embolism, and one partial disruption (30% of the circumference) of the anastomosis. Bowel control and function were excellent in 8 and good in 4 patients. Function was not yet assessable in the remaining 2 patients. © 1990, American Medical Association. All rights reserved. |
| Keywords: | adult; clinical article; aged; conference paper; preoperative care; methodology; adenocarcinoma; postoperative complications; preoperative period; neoplasm invasiveness; anastomosis; rectal neoplasms; rectum cancer; rectum resection; anastomosis, surgical; rectum; middle age; anoplasty; anus; human; male; female; priority journal |
| Journal Title: | Archives of Surgery |
| Volume: | 125 |
| Issue: | 2 |
| ISSN: | 0004-0010 |
| Publisher: | American Medical Association |
| Date Published: | 1990-02-01 |
| Start Page: | 247 |
| End Page: | 251 |
| Language: | English |
| DOI: | 10.1001/archsurg.1990.01410140125020 |
| PUBMED: | 2302064 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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