| Abstract: |
Several promising antiviral nucleosides have been tested in paired combinations against guinea pig cytomegalovirus (GPCMV) replication in guinea pig embryo (GPE) cells by plaque reduction assay; these are [9-(2-hydroxy-1-3-2-dioxaphosphorinan-5-yl)oxymethyl]-guanine P-oxide (2′nor-cGMP, compound 164), [4-amino-5-bromo-7-(2-hydroxyethoxymethyl)-pyrrolo(2,3-d)pyrimidine] (compound 102), (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC), 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG), 9-(2-hydroxyethoxymethyl)guanine (acyclovir, ACV) and 3′-azido-3′-deoxythymidine (zidovudine, AZT). Various degrees of interactions were observed; i.e. synergistic reactions were noted in the presence of compound 164/compound 102 and compound 164/DHPG combinations at all concentrations tested. HPMPC/DHPG combinations were synergistic at relatively lower concentrations of DHPG, but became antagonistic as the concentration of DHPG increased. Combinations of compound 164/ACV and DHPG/AZT were antagonistic. © 1990. |
| Keywords: |
nonhuman; animal; cells, cultured; aciclovir; in vitro study; dose-response relationship, drug; drug synergism; cidofovir; virus infection; virus replication; drug combinations; ganciclovir; cytomegalovirus; nucleoside; zidovudine; antiviral agents; drug interaction; nucleosides; plaque assay; guinea pigs; priority journal; article; sus scrofa; cavia porcellus; support, u.s. gov't, p.h.s.; support, u.s. gov't, non-p.h.s.; combined antiviral effect; dose-effect analysis; guinea pig cytomegalovirus; 4 amino 5 bromo 7 [(2 hydroxyethoxy)methyl]pyrrolo[2,3 d]pyrimidine; ganciclovir cyclic phosphate
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