Prior laparotomy or corticosterone potentiates lipopolysaccharide-induced fever and sickness behaviors Journal Article
| Authors: | Hains, L. E.; Loram, L. C.; Taylor, F. R.; Strand, K. A.; Wieseler, J. L.; Barrientos, R. M.; Young, J. J.; Frank, M. G.; Sobesky, J.; Martin, T. J.; Eisenach, J. C.; Maier, S. F.; Johnson, J. D.; Fleshner, M.; Watkins, L. R. |
| Article Title: | Prior laparotomy or corticosterone potentiates lipopolysaccharide-induced fever and sickness behaviors |
| Abstract: | Stimulating sensitized immune cells with a subsequent immune challenge results in potentiated pro-inflammatory responses translating into exacerbated sickness responses (i.e. fever, pain and lethargy). Both corticosterone (CORT) and laparotomy cause sensitization, leading to enhanced sickness-induced neuroinflammation or pain (respectively). However, it is unknown whether this sensitization affects all sickness behaviors and immune cell responses equally. We show that prior CORT and prior laparotomy potentiated LPS-induced fever but not lethargy. Prior CORT, like prior laparotomy, was able to potentiate sickness-induced pain. Release of nitric oxide (NO) from peritoneal macrophages stimulated ex vivo demonstrates that laparotomy, but not CORT sensitizes these cells. © 2011 Elsevier B.V. |
| Keywords: | controlled study; nonhuman; laparotomy; animal cell; pain; interleukin 1beta; animal experiment; animal model; fever; rat; rats; hyperthermia; cytokine release; lethargy; telemetry; sensitization; allodynia; nitric oxide; circadian rhythm; corticosterone; proinflammatory cytokines; sickness response; endotoxin; escherichia coli lipopolysaccharide; illness behavior; light dark cycle; peritoneum macrophage; prior laparotomy; stress hyperthermia |
| Journal Title: | Journal of Neuroimmunology |
| Volume: | 239 |
| Issue: | 1-2 |
| ISSN: | 0165-5728 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2011-10-28 |
| Start Page: | 53 |
| End Page: | 60 |
| Language: | English |
| DOI: | 10.1016/j.jneuroim.2011.08.011 |
| PROVIDER: | scopus |
| PMCID: | PMC3205218 |
| PUBMED: | 21907418 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 9 December 2011" - "CODEN: JNRID" - "Source: Scopus" |
