Practical approach for comparative analysis of multilesion molecular imaging using a semiautomated program for PET/CT Journal Article
| Authors: | Fox, J. J.; Autran-Blanc, E.; Morris, M. J.; Gavane, S.; Nehmeh, S.; Van Nuffel, A.; Gonen, M.; Schoder, H.; Humm, J. L.; Scher, H. I.; Larson, S. M. |
| Article Title: | Practical approach for comparative analysis of multilesion molecular imaging using a semiautomated program for PET/CT |
| Abstract: | We propose a standardized approach to quantitative molecular imaging (MI) in cancer patients with multiple lesions. Methods: Twenty patients with castration-resistant prostate cancer underwent 18F-FDG and 18F-16β-fluoro-5-dihydrotestosterone (18FFDHT) PET/CT scans. Using a 5-point confidence scale, 2 readers interpreted coregistered scan sets on a workstation. Two hundred three sites per scan (specified in a lexicon) were reviewed. 18FFDG-positive lesion bookmarks were propagated onto 18F-FDHT studies and then manually accepted or rejected. Discordancepositive 18F-FDHT lesions were similarly bookmarked. Lesional SUVmax was recorded. Tracer- and tissue-specific background correction factors were calculated via receiver-operating- characteristic analysis of 65 scan sets. Results: Readers agreed on more than 99% of 18F-FDG- and 18F-FDHT-negative sites. Positive- site agreement was 83% and 85%, respectively. Consensuslesion maximum standardized uptake value (SUVmax) was highly reproducible (concordance correlation coefficient > 0.98). Receiver-operating- characteristic curves yielded 4 correction factors (SUVmax 1.8-2.6). A novel scatterplot (Larson-Fox-Gonen plot) depicted tumor burden and change in SUVmax for response assessments. Conclusion: Multilesion molecular imaging is optimized with a 5-step approach incorporating a confidence scale, site lexicon, semiautomated PET software, background correction, and Larson-Fox-Gonen graphing. Copyright © 2011 by the Society of Nuclear Medicine, Inc. |
| Keywords: | clinical article; controlled study; retrospective studies; unclassified drug; sensitivity and specificity; reproducibility; observer variation; tumor volume; tumor markers, biological; molecular imaging; automation; prostatic neoplasms; standardization; reference standards; fluorodeoxyglucose f 18; computer assisted emission tomography; fluorodeoxyglucose f18; radiopharmaceutical agent; orchiectomy; image processing, computer-assisted; computer program; pet/ct; receiver operating characteristic; castration resistant prostate cancer; tissue specificity; 18f-fdg; dihydrotestosterone; process optimization; semi-automated; 18f-fdht; 16beta fluoro 5 dihydrotestosterone f 18; positron-emission tomography and computed tomography |
| Journal Title: | Journal of Nuclear Medicine |
| Volume: | 52 |
| Issue: | 11 |
| ISSN: | 0161-5505 |
| Publisher: | Society of Nuclear Medicine |
| Date Published: | 2011-11-01 |
| Start Page: | 1727 |
| End Page: | 1732 |
| Language: | English |
| DOI: | 10.2967/jnumed.111.089326 |
| PROVIDER: | scopus |
| PUBMED: | 21984797 |
| PMCID: | PMC3409842 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 9 December 2011" - "CODEN: JNMEA" - "Source: Scopus" |
