Marrow storage techniques: A clinical comparison of refrigeration versus cryopreservation Journal Article
| Authors: | Ahmed, T.; Wuest, D.; Ciavarella, D.; Ayello, J.; Feldman, E. J.; Biguzzi, S.; Gulati, S.; Hussain, F.; Mittelman, A.; Ascensao, J. L.; Arlin, Z. A. |
| Article Title: | Marrow storage techniques: A clinical comparison of refrigeration versus cryopreservation |
| Abstract: | Fifty-three patients were evaluated for a comparison of the efficacy, safety, and cost efficiency of bone marrow (BM) transplanted after either refrigeration or cryopreservation. Thirty-eight patients had BM stored at 4-degrees-C for an average of 3 days and 15 patients had cryopreserved BM stored for an average of 56 days. The average number of cells harvested was 3.8 x 10(8)/kg. The time to WBC recovery > 1 x 10(9)/l was 17 days refrigerated and 23 days for cryopreserved BM. The time to platelet recovery > 20 x 10(9)/l was 24 days for refrigeration storage and 51 days for cryopreserved BM. Four of 38 patients with refrigerated vs. 4/15 patients with cryopreserved BM experienced delayed engraftment (p < 0.05). Refrigeration storage requires no special equipment, is cheaper than and presents a safe and viable alternative to cryopreserved BM in reconstituting hemopoiesis following high-dose chemo-radiotherapy. |
| Keywords: | leukemia; chemotherapy; bone marrow; transplantation; cryopreservation; engraftment; bone marrow transplantation; therapy; hodgkins-disease; high-dose; malignant-lymphoma; autologous bone-marrow; high-dose cyclophosphamide; 4-hydroperoxycyclophosphamide; refrigeration |
| Journal Title: | Acta Haematologica |
| Volume: | 85 |
| Issue: | 4 |
| ISSN: | 0001-5792 |
| Publisher: | S. Karger AG |
| Date Published: | 1991-01-01 |
| Start Page: | 173 |
| End Page: | 178 |
| Language: | English |
| ACCESSION: | WOS:A1991FW73100001 |
| PROVIDER: | wos |
| PUBMED: | 1906669 |
| DOI: | 10.1159/000204886 |
| Notes: | Article -- Source: Wos |
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