Hiding the road signs that lead to tumor immunity Journal Article
| Authors: | Schaer, D. A.; Lesokhin, A. M.; Wolchok, J. D. |
| Article Title: | Hiding the road signs that lead to tumor immunity |
| Abstract: | Tumors exploit many strategies to evade T cell-mediated destruction. For example, tumors can prevent T cell infiltration by modifying gene expression in the endothelial cells and pericytes that form their vasculature. New work showing that the T cell-attracting chemokine CCL2 can be posttranslationally modified in the tumor microenvironment adds another mechanism to the already formidable arsenal of immunoevasion tactics used by solid tumors. © 2011 Schaer et al. |
| Keywords: | nonhuman; solid tumor; neoplasms; cd8 antigen; t lymphocyte; tumor associated leukocyte; t-lymphocytes; gene expression; endothelium cell; tumor immunity; short survey; lymphocytic infiltration; tumor vascularization; intercellular adhesion molecule 1; immunotherapy, adoptive; chemokine receptor ccr2; receptors, ccr2; monocyte chemotactic protein 1; chemokine ccl2; tumor microenvironment; pericyte; reactive nitrogen species |
| Journal Title: | Journal of Experimental Medicine |
| Volume: | 208 |
| Issue: | 10 |
| ISSN: | 0022-1007 |
| Publisher: | Rockefeller University Press |
| Date Published: | 2011-09-26 |
| Start Page: | 1937 |
| End Page: | 1940 |
| Language: | English |
| DOI: | 10.1084/jem.20111856 |
| PUBMED: | 21948803 |
| PROVIDER: | scopus |
| PMCID: | PMC3182053 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 9 December 2011" - "CODEN: JEMEA" - "Source: Scopus" |
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