Intraoperative and postanesthesia care unit fluid administration as risk factors for postoperative complications in patients with head and neck cancer undergoing free tissue transfer Journal Article


Authors: Dooley, B. J.; Karassawa Zanoni, D.; McGill, M. R.; Awad, M. I.; Shah, J. P.; Wong, R. J.; Broad, C.; Mehrara, B. J.; Ganly, I.; Patel, S. G.
Article Title: Intraoperative and postanesthesia care unit fluid administration as risk factors for postoperative complications in patients with head and neck cancer undergoing free tissue transfer
Abstract: Background: This study aims to evaluate the impact of perioperative fluid administration, defined as fluid delivered intraoperatively and in the postanesthesia care unit, on postoperative outcomes. Methods: Medical records of 102 patients with oral cavity squamous cell carcinoma undergoing free flap reconstruction between January 2011 and December 2015 were reviewed. The primary endpoint was development of a postoperative complication according to the Clavien-Dindo classification. Perioperative factors recorded were Washington University Head and Neck Comorbidity Index, operating time, vasopressor use, blood loss, intraoperative fluid, and perioperative fluid. Results: Greater perioperative fluid administration was independently associated with surgical complications, flap complications, overall incidence of any complication, and increased length of stay. Greater intraoperative fluid administration was independently associated with higher rates of surgical complications. Intraoperative delivery of vasopressors was not associated with flap or surgical complications. Conclusion: Receiving less perioperative fluid was associated with fewer complications and decreased length of stay. © 2019 Wiley Periodicals, Inc.
Keywords: adult; aged; major clinical study; disease classification; outcome assessment; bleeding; fluid therapy; medical record review; risk factor; postoperative complication; length of stay; correlation analysis; graft failure; head and neck cancer; intraoperative period; operation duration; clinical evaluation; perioperative period; free tissue graft; mouth cavity; hypertensive factor; postanesthesia care unit; recovery room; clinical assessment tool; lung complication; mouth squamous cell carcinoma; free tissue transfer; intraoperative fluid; oral cavity squamous cell carcinoma; human; male; female; priority journal; article; perioperative fluid; clavien dindo classification; washington university head and neck comorbidity index
Journal Title: Head & Neck
Volume: 42
Issue: 1
ISSN: 1043-3074
Publisher: John Wiley & Sons, Inc.  
Date Published: 2020-01-01
Start Page: 14
End Page: 24
Language: English
DOI: 10.1002/hed.25970
PUBMED: 31593349
PROVIDER: scopus
PMCID: PMC7544020
DOI/URL:
Notes: Article -- Source: Scopus
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MSK Authors
  1. Snehal G Patel
    412 Patel
  2. Babak Mehrara
    448 Mehrara
  3. Richard J Wong
    412 Wong
  4. Ian Ganly
    430 Ganly
  5. Jatin P Shah
    721 Shah
  6. Mahmoud Issam Awad
    10 Awad
  7. Clara   Broad
    2 Broad
  8. Marlena Rose McGill
    24 McGill
  9. Bryan Dooley
    1 Dooley