Deep learning-based auto-segmentation of targets and organs-at-risk for magnetic resonance imaging only planning of prostate radiotherapy Journal Article
| Authors: | Elguindi, S.; Zelefsky, M. J.; Jiang, J.; Veeraraghavan, H.; Deasy, J. O.; Hunt, M. A.; Tyagi, N. |
| Article Title: | Deep learning-based auto-segmentation of targets and organs-at-risk for magnetic resonance imaging only planning of prostate radiotherapy |
| Abstract: | Background and purpose: Magnetic resonance (MR) only radiation therapy for prostate treatment provides superior contrast for defining targets and organs-at-risk (OARs). This study aims to develop a deep learning model to leverage this advantage to automate the contouring process. Materials and methods: Six structures (bladder, rectum, urethra, penile bulb, rectal spacer, prostate and seminal vesicles) were contoured and reviewed by a radiation oncologist on axial T2-weighted MR image sets from 50 patients, which constituted expert delineations. The data was split into a 40/10 training and validation set to train a two-dimensional fully convolutional neural network, DeepLabV3+, using transfer learning. The T2-weighted image sets were pre-processed to 2D false color images to leverage pre-trained (from natural images) convolutional layers’ weights. Independent testing was performed on an additional 50 patient's MR scans. Performance comparison was done against a U-Net deep learning method. Algorithms were evaluated using volumetric Dice similarity coefficient (VDSC) and surface Dice similarity coefficient (SDSC). Results: When comparing VDSC, DeepLabV3+ significantly outperformed U-Net for all structures except urethra (P < 0.001). Average VDSC was 0.93 ± 0.04 (bladder), 0.83 ± 0.06 (prostate and seminal vesicles [CTV]), 0.74 ± 0.13 (penile bulb), 0.82 ± 0.05 (rectum), 0.69 ± 0.10 (urethra), and 0.81 ± 0.1 (rectal spacer). Average SDSC was 0.92 ± 0.1 (bladder), 0.85 ± 0.11 (prostate and seminal vesicles [CTV]), 0.80 ± 0.22 (penile bulb), 0.87 ± 0.07 (rectum), 0.85 ± 0.25 (urethra), and 0.83 ± 0.26 (rectal spacer). Conclusion: A deep learning-based model produced contours that show promise to streamline an MR-only planning workflow in treating prostate cancer. © 2019 The Authors |
| Keywords: | prostate cancer; deep learning; autosegmentation; mr-only; u-net |
| Journal Title: | Physics and Imaging in Radiation Oncology |
| Volume: | 12 |
| ISSN: | 2405-6316 |
| Publisher: | Elsevier B.V. |
| Date Published: | 2019-10-01 |
| Start Page: | 80 |
| End Page: | 86 |
| Language: | English |
| DOI: | 10.1016/j.phro.2019.11.006 |
| PROVIDER: | scopus |
| PMCID: | PMC7192345 |
| PUBMED: | 32355894 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work