DNA ligase III: A spotty presence in eukaryotes, but an essential function where tested Journal Article
| Authors: | Simsek, D.; Jasin, M. |
| Article Title: | DNA ligase III: A spotty presence in eukaryotes, but an essential function where tested |
| Abstract: | DNA ligases are crucial for most DNA transactions, including DNA replication, repair and recombination. Recently, DNA ligase III (Lig3) has been demonstrated to be crucial for cell survival due to its catalytic function in mitochondria. This review summarizes these recent results and reports on a hitherto unappreciated widespread phylogenetic presence of Lig3 in eukaryotes, including in some organisms before the divergence of metazoa. Analysis of these putative Lig3 homologs suggests that many of them are likely to be found in mitochondria and to be critical for mitochondrial function. © 2011 Landes Bioscience. |
| Keywords: | unclassified drug; gene sequence; gene deletion; genetics; review; nonhuman; dna replication; cell viability; dna damage; cell function; dna repair; drosophila; gene function; eukaryota; gene interaction; escherichia coli; hydrogen peroxide; cell nucleus; dna metabolism; molecular biology; polydeoxyribonucleotide synthase; zinc finger protein; mitochondrion; eukaryote; dna ligases; metazoa; phylogeny; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase 1; salmonella typhimurium; xrcc1 protein; polydeoxyribonucleotide synthase iii; genome integrity; caenorhabditis; cell nucleus dna; creatine kinase mm; anopheles; ascaris; barley; metazoon; naegleria gruberi |
| Journal Title: | Cell Cycle |
| Volume: | 10 |
| Issue: | 21 |
| ISSN: | 1538-4101 |
| Publisher: | Taylor & Francis Inc. |
| Date Published: | 2011-11-01 |
| Start Page: | 3636 |
| End Page: | 3644 |
| Language: | English |
| DOI: | 10.4161/cc.10.21.18094 |
| PROVIDER: | scopus |
| PUBMED: | 22041657 |
| PMCID: | PMC3266004 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 9 December 2011" - "Source: Scopus" |
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