Inotuzumab ozogamicin as chemotherapy-sparing salvage in a 67-year-old man with primary refractory B-cell acute lymphoblastic leukemia with high-risk genomic features Journal Article

   

Authors:	Yang, X.; Sen, F.; Geyer, M. B.
Article Title:	Inotuzumab ozogamicin as chemotherapy-sparing salvage in a 67-year-old man with primary refractory B-cell acute lymphoblastic leukemia with high-risk genomic features
Abstract:	Older adults with acute lymphoblastic leukemia (ALL) continue to have a poor prognosis, in part due to greater chemotherapy-related toxicities. We herein report a 67-year-old man with Philadelphia chromosome (Ph)-negative B-cell ALL, who exhibited refractoriness to 3 different regimens of induction chemotherapy and experienced multiple complications including intracranial bleeding and respiratory failure, who achieved minimal residual disease (MRD)-negative complete response (CR) after a single cycle of inotuzumab ozogamicin (IO). His ALL was characterized by several high-risk mutations, which may have contributed to chemotherapy-refractory disease. Our case supports incorporating IO into front-line induction regimens for older adults with high-risk B-cell ALL. © 2019
Keywords:	clinical article; aged; primary tumor; gene mutation; case report; cancer risk; antineoplastic agent; cancer immunotherapy; acute lymphoblastic leukemia; high risk patient; cancer resistance; immunotherapy; genetic risk; brain hemorrhage; induction chemotherapy; respiratory failure; b cell leukemia; inotuzumab ozogamicin; philadelphia chromosome negative cell; older adults; human; male; priority journal; article
Journal Title:	Leukemia Research Reports
Volume:	12
ISSN:	2213-0489
Publisher:	Elsevier Inc.
Date Published:	2019-01-01
Start Page:	100186
Language:	English
DOI:	10.1016/j.lrr.2019.100186
PROVIDER:	scopus
PMCID:	PMC6904788
PUBMED:	31867204
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85075731921&doi=10.1016%2fj.lrr.2019.100186&partnerID=40&md5=963b6ebe1f8bc9cfe23bf5a8a3652824
Notes:	Article -- Source: Scopus

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