Cytologic features of epithelioid hemangioendothelioma Journal Article


Authors: Murali, R.; Zarka, M. A.; Ocal, I. T.; Tazelaar, H. D.
Article Title: Cytologic features of epithelioid hemangioendothelioma
Abstract: To determine cytologic features of epithelioid hemangioendothelioma (EHE) that would enable accurate diagnosis, we evaluated fine-needle aspiration biopsy (FNAB) smears from 11 histologically confirmed EHEs. The variably cellular smears compriseddispersed single cells and occasional cell aggregates. Dense stromal fragments were present in association with some tissue fragments. The cells were epithelioid, containing moderate or large amounts of dense cytoplasm. Nuclei exhibited mild pleomorphism, and nuclear grooves were identified in all cases. At least occasional intranuclear pseudoinclusions (INPIs) and intracytoplasmic lumina (ICLs) were present in all cases and in 9 cases (82%), respectively, and rare erythrocytes were seen within ICLs in 5 cases (45%). Mitotic figures were identified in 4 cases (36%). The background was bloody in 6 cases (55%) and contained hemosiderin and/or hemosiderin-laden macrophages in 5 cases (45%). The combination of the following features in FNAB samples should raise strong suspicion for EHE: predominantly dispersed single cells with occasional cohesive cell clusters; epithelioid cytomorphology; dense cytoplasm with well-defined cytoplasmic borders; ICLs (with or without erythrocytes), INPIs, and nuclear grooves. The presence of these features should prompt correlation with clinical, radiologic, and histologic features and immunohistochemical evaluation using vascular markers. © American Society for Clinical Pathology.
Keywords: adult; clinical article; human tissue; aged; human cell; clinical feature; histopathology; diagnostic accuracy; mitosis; cytology; cell structure; pathology; diagnosis; cytoplasm; cell aggregation; erythrocyte; aspiration biopsy; macrophage; epithelioid cell; cytodiagnosis; hemangioendothelioma; vascular tumors; hemosiderin; epithelioid hemangioendothelioma; fine-needle biopsy
Journal Title: American Journal of Clinical Pathology
Volume: 136
Issue: 5
ISSN: 0002-9173
Publisher: Oxford University Press  
Date Published: 2011-11-01
Start Page: 739
End Page: 746
Language: English
DOI: 10.1309/ajcp5nk0fjcghtfm
PROVIDER: scopus
PUBMED: 22031312
DOI/URL:
Notes: --- - "Export Date: 9 December 2011" - "CODEN: AJCPA" - "Source: Scopus"
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  1. Rajmohan Murali
    219 Murali