Cutaneous squamous cell carcinoma of the head and neck metastasizing to the parotid gland - A review of current recommendations Journal Article
| Authors: | O'Hara, J.; Ferlito, A.; Takes, R. P.; Rinaldo, A.; Strojan, P.; Shaha, A. R.; Rodrigo, J. P.; Paleri, V. |
| Article Title: | Cutaneous squamous cell carcinoma of the head and neck metastasizing to the parotid gland - A review of current recommendations |
| Abstract: | Cutaneous squamous cell carcinoma (SCC) of the head and neck may metastasize in up to 5% of patients, with the parotid lymph nodes the most frequent site for spread. Metastases frequently show delayed presentation after the primary cancer had been treated. The optimum treatment should be surgery followed by adjuvant radiotherapy, with an appropriate parotidectomy, and preservation of the facial nerve if not involved by tumor and treatment to the neck. In a clinically N0 neck, levels I to III should be cleared for facial primaries, levels II to III for anterior scalp and external ear primaries, and levels II to V for posterior scalp primaries. Approximate 5-year disease-specific survival (DSS) after treatment was 70% to 75%. Patients with immunosuppression, in particular transplant recipients, are at high risk of developing aggressive metastatic cutaneous SCC. Modifications of the staging systems have demonstrated the prognostic benefits of accurately staging parotid and/or neck nodal disease. © 2010 Wiley Periodicals, Inc. |
| Keywords: | cancer chemotherapy; cancer survival; cancer surgery; primary tumor; cancer localization; neck dissection; squamous cell carcinoma; carcinoma, squamous cell; cancer risk; cancer adjuvant therapy; disease free survival; cancer staging; nuclear magnetic resonance imaging; follow up; lymph node metastasis; sentinel lymph node biopsy; skin neoplasms; radiotherapy; risk factors; cancer invasion; electron therapy; head and neck neoplasms; computer assisted emission tomography; surgery; aspiration biopsy; immune deficiency; parotid gland; parotid neoplasms; graft recipient; head and neck carcinoma; immunocompromised patient; cutaneous squamous cell carcinoma; skin color; parotidectomy; lymph node metastases |
| Journal Title: | Head & Neck |
| Volume: | 33 |
| Issue: | 12 |
| ISSN: | 1043-3074 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 2011-12-01 |
| Start Page: | 1789 |
| End Page: | 1795 |
| Language: | English |
| DOI: | 10.1002/hed.21583 |
| PROVIDER: | scopus |
| PUBMED: | 22076982 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 9 December 2011" - "CODEN: HEANE" - "Source: Scopus" |
