Clinical implications of novel mutations in epigenetic modifiers in AML Journal Article


Authors: Abdel-Wahab, O.; Patel, J.; Levine, R. L.
Article Title: Clinical implications of novel mutations in epigenetic modifiers in AML
Abstract: Increased understanding of the molecular genetics of acute myeloid leukemia (AML) has uncovered several mutations in genes with a role in the epigenetic regulation of gene transcription, including mutations in TET2, IDH1, IDH2, and DNMT3a. This article reviews recent studies investigating the clinical importance of these mutations in AML, and specifically discusses the efficacy of molecular analysis for these mutations in refining prognosis in AML and informing therapeutic management of patients with AML. © 2011 Elsevier Inc.
Keywords: cancer chemotherapy; cancer survival; event free survival; unclassified drug; oncoprotein; acute granulocytic leukemia; gene mutation; genetic trait; gene deletion; mutation; dna-binding proteins; leukemia, myeloid, acute; proto-oncogene proteins; allogeneic stem cell transplantation; review; disease classification; cancer patient; disease free survival; cytarabine; genotype; cytogenetics; dna methylation; risk factor; myelodysplastic syndrome; neoplasm, residual; epigenetics; epigenesis, genetic; daunorubicin; cancer relapse; flt3 ligand; anthracycline; dna (cytosine-5-)-methyltransferase; isocitrate dehydrogenase; protein tet2; transcription factor runx1; dna methyltransferase 3a; core binding factor; idh1; aml; isocitrate dehydrogenase 1; isocitrate dehydrogenase isoenzyme; nucleophosmin; 5 methylcytosine; tet2; idh2; ccaat enhancer binding protein alpha; reduced nicotinamide adenine dinucleotide phosphate; dnmt3a; cytogenetically normal acute granulocytic leukemia; gain of function mutation
Journal Title: Hematology/Oncology Clinics of North America
Volume: 25
Issue: 6
ISSN: 0889-8588
Publisher: Elsevier Inc.  
Date Published: 2011-12-01
Start Page: 1119
End Page: 1133
Language: English
DOI: 10.1016/j.hoc.2011.09.013
PROVIDER: scopus
PUBMED: 22093580
DOI/URL:
Notes: --- - "Export Date: 9 December 2011" - "CODEN: HCNAE" - "Source: Scopus"
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MSK Authors
  1. Ross Levine
    513 Levine
  2. Jay Prakash Patel
    54 Patel