Surgical resection of granular cell tumor of the sellar region: Three indications Journal Article
| Authors: | Ahmed, A. K.; Dawood, H. Y.; Cote, D. J.; Bale, T. A.; De Girolami, U.; Laws, E. R. Jr; Smith, T. R. |
| Article Title: | Surgical resection of granular cell tumor of the sellar region: Three indications |
| Abstract: | Purpose: This case series evaluates the surgical management of granular cell tumor (GCT) of the sellar region. This rare entity presents a unique diagnostic and surgical challenge. Methods: Institutional neuropathology databases at Brigham and Women’s Hospital and Massachusetts General Hospital were searched for cases with a tissue diagnosis of GCT, and with a location in the sellar region. Patient, treatment, tumor, and follow-up data were extracted. Results: Three patients had a diagnosis of GCT of the sellar region occurring over an 18-year period. All three patients were followed postoperatively at our multidisciplinary pituitary center (median follow-up = 30 months; range 12–30 months). Hormonal disturbances, an incidental lesion requiring diagnosis, and neurological symptoms were indications for surgery in these patients. Two patients underwent a craniotomy and one underwent endoscopic transsphenoidal surgery. All three patients were free of tumor recurrence at last follow-up. In one case tested, positive thyroid transcription factor-1 (TTF-1) immunohistochemistry was observed. Conclusion: GCT is generally a benign tumor of the sellar region. Surgical resection is the standard treatment, more recently with transsphenoidal surgery when indicated. Surgical resection results in optimal outcome for patients. © 2019, Springer Science+Business Media, LLC, part of Springer Nature. |
| Keywords: | adult; clinical article; human tissue; treatment response; middle aged; prednisone; histopathology; case report; postoperative period; neuroimaging; nuclear magnetic resonance imaging; treatment indication; cell proliferation; radiation; tumor volume; glial fibrillary acidic protein; confusion; disease severity; basilar artery; tumor recurrence; endoscopic surgery; protein s 100; craniotomy; headache; craniopharyngioma; optic nerve; hydrocortisone; hypothyroidism; neurologic disease; testosterone; esophagus carcinoma; visual impairment; optic chiasm; hormone substitution; female infertility; vasopressin; case study; hormone release; medical history; galectin 3; hyperprolactinemia; bromocriptine; granular cell tumor; vaginal delivery; transsphenoidal; perimetry; oculomotor nerve; ophthalmoplegia; hypophysis adenoma; transsphenoidal surgery; hormone deficiency; nerve compression; pituicytoma; human; male; female; priority journal; article; optic tract; posterior cerebral artery; homeobox protein nkx 2.1; mammillary body; pituitary stalk; spider bite |
| Journal Title: | Pituitary |
| Volume: | 22 |
| Issue: | 6 |
| ISSN: | 1386-341X |
| Publisher: | Springer |
| Date Published: | 2019-12-01 |
| Start Page: | 633 |
| End Page: | 639 |
| Language: | English |
| DOI: | 10.1007/s11102-019-00999-z |
| PUBMED: | 31620953 |
| PROVIDER: | scopus |
| PMCID: | PMC8080114 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
