Development of nomograms to predict the recovery of erectile function following radical prostatectomy Journal Article

   


Authors: Mulhall, J. P.; Kattan, M. W.; Bennett, N. E.; Stasi, J.; Nascimento, B.; Eastham, J.; Guillonneau, B.; Scardino, P. T.
Article Title: Development of nomograms to predict the recovery of erectile function following radical prostatectomy
Abstract: Introduction: Given the number of confounders in predicting erectile function recovery after radical prostatectomy (RP), a nomogram predicting the chance to be functional after RP would be useful to patients’ and clinicians’ discussions. Aim: To develop preoperative and postoperative nomograms to aid in the prediction of erectile function recovery after RP. Main Outcome Measures: International Index of Erectile Function (IIEF) erectile function domain score-based erectile function. Methods: A prospective quality-of-life database was used to develop a series of nomograms using multivariable ordinal logistic regression models. Standard preoperative and postoperative factors were included. Main Outcome Measures: The nomograms predicted the probability of recovering functional erections (erectile function domain scores ≥24) and severe erectile dysfunction (≤10) 2 years after RP. Results: 3 nomograms have been developed, including a preoperative, an early postoperative, and a 12-month postoperative version. The concordance indexes for all 3 exceeded 0.78, and the calibration was good. Clinical Implications: These nomograms may aid clinicians in discussing erectile function recovery with patients undergoing RP. Strengths & Limitations: Strengths of this study included a large population, validated instrument, nerve-sparing grading, and nomograms that are well calibrated with excellent discrimination ability. Limitations include current absence of external validation and an overall low comorbidity index. Conclusions: It is hoped that these nomograms will allow for a more accurate discussion between patients and clinicians regarding erectile function recovery after RP. Mulhall JP, Kattan MW, Bennett NE, et al. Development of Nomograms to Predict the Recovery of Erectile Function Following Radical Prostatectomy J Sex Med 2019;16:1796–1802. © 2019 International Society for Sexual Medicine
Keywords: adult; major clinical study; disease course; postoperative period; calibration; prediction; prostate cancer; preoperative period; prostatectomy; nomograms; radical prostatectomy; erectile dysfunction; nomogram; penis erection; international index of erectile function; human; male; priority journal; article
Journal Title: Journal of Sexual Medicine
Volume: 16
Issue: 11
ISSN: 1743-6095
Publisher: Elsevier Inc.  
Date Published: 2019-11-01
Start Page: 1796
End Page: 1802
Language: English
DOI: 10.1016/j.jsxm.2019.08.003
PUBMED: 31521569
PROVIDER: scopus
PMCID: PMC6833944
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85072020095&doi=10.1016%2fj.jsxm.2019.08.003&partnerID=40&md5=59260b4785cd5295084550161ce75ab9
Notes: Source: Scopus
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MSK Authors
  1. Peter T Scardino
    671 Scardino
  2. Bertrand Guillonneau
    137 Guillonneau
  3. John P Mulhall
    601 Mulhall
  4. James Eastham
    537 Eastham
  5. Jason Stasi
    26 Stasi
  6. Bruno C Gouveia Nascimento
    28 Gouveia Nascimento
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