Clinical utilization of chimeric antigen receptor T-cells (CAR-T) in B-cell acute lymphoblastic leukemia (ALL) - An expert opinion from the European Society for Blood and Marrow Transplantation (EBMT) and the American Society for Blood and Marrow Transplantation (ASBMT) Journal Article


Authors: Kansagra, A. J.; Frey, N. V.; Bar, M.; Laetsch, T. W.; Carpenter, P. A.; Savani, B. N.; Heslop, H. E.; Bollard, C. M.; Komanduri, K. V.; Gastineau, D. A.; Chabannon, C.; Perales, M. A.; Hudecek, M.; Aljurf, M.; Andritsos, L.; Barrett, J. A.; Bachanova, V.; Bonini, C.; Ghobadi, A.; Gill, S. I.; Hill, J. A.; Kenderian, S.; Kebriaei, P.; Nagler, A.; Maloney, D.; Liu, H. D.; Shah, N. N.; Kharfan-Dabaja, M. A.; Shpall, E. J.; Mufti, G. J.; Johnston, L.; Jacoby, E.; Bazarbachi, A.; DiPersio, J. F.; Pavletic, S. Z.; Porter, D. L.; Grupp, S. A.; Sadelain, M.; Litzow, M. R.; Mohty, M.; Hashmi, S. K.
Article Title: Clinical utilization of chimeric antigen receptor T-cells (CAR-T) in B-cell acute lymphoblastic leukemia (ALL) - An expert opinion from the European Society for Blood and Marrow Transplantation (EBMT) and the American Society for Blood and Marrow Transplantation (ASBMT)
Abstract: On August 30, 2017, the U.S. Food and Drug Administration (US-FDA) approved tisagenlecleucel (KYMRIAH, Novartis, Basel, Switzerland), a synthetic bioimmune product of anti-CD19 chimeric antigen receptor-T cells (CAR-T), for the treatment of children and young adults with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL). With this new era of personalized cancer immunotherapy, multiple challenges are present ranging from implementation of a CAR-T program to safe delivery of the drug, long-term toxicity monitoring and disease assessments. To address these issues, experts representing the American Society for Blood and Marrow Transplant (ASBMT), the European Group for Blood and Marrow Transplantation (EBMT), the International Society of Cell and Gene Therapy (ISCT), and the Foundation for the Accreditation of Cellular Therapy (FACT), formed a global CAR-T task force to identify and address key questions pertinent for hematologists and transplant physicians regarding the clinical use of anti CD19 CAR-T therapy in patients with B-ALL. This article presents an initial roadmap for navigating common clinical practice scenarios that will become more prevalent now that the first commercially available CAR-T product for B-ALL has been approved. © 2019, Springer Nature Limited.
Keywords: cancer chemotherapy; treatment response; fludarabine; allogeneic stem cell transplantation; cancer patient; t lymphocyte; cancer immunotherapy; etoposide; delirium; aciclovir; cyclophosphamide; immunoglobulin; steroid; herpes simplex; acute lymphoblastic leukemia; confusion; vaccination; surgeon; brain disease; seizure; headache; myoclonus; corticosteroid; ataxic aphasia; bone marrow transplantation; cotrimoxazole; levofloxacin; bacterial infection; immunoglobulin deficiency; fluconazole; pentamidine; candidiasis; patient referral; micafungin; chickenpox; brain edema; inotuzumab ozogamicin; pneumocystis; cytokine release syndrome; valaciclovir; pneumocystosis; hematologist; aplasia; tocilizumab; levetiracetam; blinatumomab; b cell aplasia; human; priority journal; article; malignant neoplasm; tisagenlecleucel t; chimeric antigen receptor t-cell immunotherapy
Journal Title: Bone Marrow Transplantation
Volume: 54
Issue: 11
ISSN: 0268-3369
Publisher: Nature Publishing Group  
Date Published: 2019-11-01
Start Page: 1868
End Page: 1880
Language: English
DOI: 10.1038/s41409-019-0451-2
PUBMED: 31092900
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 2 December 2019 -- Source: Scopus
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  1. Miguel-Angel Perales
    463 Perales
  2. Michel W J Sadelain
    489 Sadelain