A mouse plasma peptide atlas as a resource for disease proteomics Journal Article
| Authors: | Zhang, Q.; Menon, R.; Deutsch, E. W.; Pitteri, S. J.; Faca, V. M.; Wang, H.; Newcomb, L. F.; DePinho, R. A.; Bardeesy, N.; Dinulescu, D.; Hung, K. E.; Kucherlapati, R.; Jacks, T.; Politi, K.; Aebersold, R.; Omenn, G. S.; States, D. J.; Hanash, S. M. |
| Article Title: | A mouse plasma peptide atlas as a resource for disease proteomics |
| Abstract: | We present an in-depth analysis of mouse plasma leading to the development of a publicly available repository composed of 568 liquid chromatography-tandem mass spectrometry runs. A total of 13,779 distinct peptides have been identified with high confidence. The corresponding approximately 3,000 proteins are estimated to span a 7 logarithmic range of abundance in plasma. A major finding from this study is the identification of novel isoforms and transcript variants not previously predicted from genome analysis. © 2008 Zhang et al.; licensee BioMed Central Ltd. |
| Keywords: | controlled study; nonhuman; mass spectrometry; proteome; mouse; animal; animals; mice; protein; peptide; proteomics; databases, protein; genome analysis; chemistry; alternative splicing; peptides; alternative rna splicing; tandem mass spectrometry; protein database; liquid chromatography; information system; plasma; isoprotein; protein isoforms |
| Journal Title: | Genome Biology |
| Volume: | 9 |
| Issue: | 6 |
| ISSN: | 1465-6906 |
| Publisher: | Biomed Central Ltd |
| Date Published: | 2008-06-03 |
| Start Page: | R93 |
| Language: | English |
| DOI: | 10.1186/gb-2008-9-6-r93 |
| PUBMED: | 18522751 |
| PROVIDER: | scopus |
| PMCID: | PMC2481425 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 8" - "Export Date: 17 November 2011" - "CODEN: GNBLF" - "Source: Scopus" |
