Does breast density increase the risk of re-excision for women with breast cancer having breast-conservation therapy? Journal Article
| Authors: | Walsh, S. M.; Brennan, S. B.; Zabor, E. C.; Rosenberger, L. H.; Stempel, M.; Lebron-Zapata, L.; Gemignani, M. L. |
| Article Title: | Does breast density increase the risk of re-excision for women with breast cancer having breast-conservation therapy? |
| Abstract: | Background: Women with dense breasts may have less-accurate preoperative evaluation of extent of disease, potentially affecting the achievement of negative margins. The goal of this study is to examine the association between breast density and re-excision rates in women having breast-conserving surgery for invasive breast cancer. Patients and Methods: Women with stage I/II invasive breast cancer treated with breast-conserving surgery between 1/1/2014 and 10/31/2014 were included. Breast density was assessed by two radiologists. The association between breast density and re-excision was examined using logistic regression. Results: Seven hundred and one women were included. Overall, 106 (15.1%) women had at least one re-excision. Younger age at diagnosis was associated with increased breast density (p < 0.001). On univariable analysis, increased breast density was associated with significantly increased odds of re-excision (odds ratio [OR] 1.38, 95% confidence interval [CI] 1.04–1.83), as was multifocal disease, human epidermal growth factor receptor 2 (HER2) positive status, and extensive intraductal component (EIC) (all p < 0.05). On multivariable analysis, breast density remained significantly associated with increased odds of re-excision (OR 1.37, 95% CI 1.00–1.86), as did multifocality and EIC. HER2 positive status was not significantly associated with re-excision on multivariable analysis. Conclusions: Women with dense breasts are more likely to need additional surgery (re-excision after breast-conserving surgery), but increased breast density did not adversely affect disease-free survival in our study. Our findings support the need for further study in developing techniques that can help decrease re-excisions for women with dense breasts who undergo breast-conserving surgery. © 2019, Society of Surgical Oncology. |
| Journal Title: | Annals of Surgical Oncology |
| Volume: | 26 |
| Issue: | 13 |
| ISSN: | 1068-9265 |
| Publisher: | Springer |
| Date Published: | 2019-12-01 |
| Start Page: | 4246 |
| End Page: | 4253 |
| Language: | English |
| DOI: | 10.1245/s10434-019-07647-7 |
| PUBMED: | 31396783 |
| PROVIDER: | scopus |
| PMCID: | PMC6868322 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 December 2019 -- Source: Scopus |
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