Low-level inhibition of Hsp90 forces cells to tip their (antigenic) hand Editorial
| Authors: | Srivastava, P. K.; Callahan, M. K. |
| Title: | Low-level inhibition of Hsp90 forces cells to tip their (antigenic) hand |
| Abstract: | Low-level inhibition of hsp90 enhances the antigenicity of cells whereas high-level inhibition diminishes antigenicity. The mechanism(s) by which hsp90 determines antigenicity are only partially clear. Regardless, these observations have profound implications in protein trafficking and antigen presentation and suggest a novel way to enhance the potency of existing anticancer agents. ©2019 American Association for Cancer Research. |
| Keywords: | protein expression; mutant protein; protein function; antigen expression; proteasome; cancer inhibition; antigen presentation; protein transport; heat shock protein 90 inhibitor; heat shock protein 90; immunological adjuvant; protein folding; cell level; mouse model; antigenicity; priority journal; article; cell antigenicity |
| Journal Title: | Clinical Cancer Research |
| Volume: | 25 |
| Issue: | 21 |
| ISSN: | 1078-0432 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2019-11-01 |
| Start Page: | 6277 |
| End Page: | 6279 |
| Language: | English |
| DOI: | 10.1158/1078-0432.Ccr-19-2094 |
| PUBMED: | 31444251 |
| PROVIDER: | scopus |
| PMCID: | PMC6825573 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 December 2019 -- Source: Scopus |
