Globular C1q receptor (gC1qR/p32/HABP1) is overexpressed in malignant pleural mesothelioma and is associated with increased survival in surgical patients treated with chemotherapy Journal Article

   

Authors:	Li, X.; Eguchi, T.; Aly, R. G.; Chintala, N. K.; Tan, K. S.; Zauderer, M. G.; Dembitzer, F. R.; Beasley, M. B.; Ghebrehiwet, B.; Adusumilli, P. S.; Peerschke, E. I. B.
Article Title:	Globular C1q receptor (gC1qR/p32/HABP1) is overexpressed in malignant pleural mesothelioma and is associated with increased survival in surgical patients treated with chemotherapy
Abstract:	Introduction: Globular C1q receptor (gC1qR/p32/HABP1) is overexpressed in a variety of cancers, particularly adenocarcinomas. This study investigated gC1qR expression in malignant pleural mesothelioma (MPM) and its pathophysiologic correlates in a surgical patient cohort. Methods: Tissue microarrays comprising 6 tumoral and 3 stromal cores from 265 patients with MPM (216 epithelioid, 26 biphasic, and 23 sarcomatoid; 1989–2010) were investigated by immunohistochemistry for gC1qR expression (intensity and distribution by H-score, range 0–300), and immune cell infiltration. Overall survival (OS) was analyzed by the Kaplan-Meier method (high vs. low gC1qR expression delineated by median score) in the whole cohort and by neoadjuvant chemotherapy (NAC) status. Multivariable Cox analysis included stage, chemotherapy, and immune cell infiltration. Results: gC1qR was overexpressed in all histological types of MPMs (263/265, 99.2%) compared to normal pleura. In epithelioid MPM, high gC1qR expression was associated with better OS (median 25 vs. 11 months; p = 0.020) among NAC patients, and among patients without NAC (No-NAC) but who received post-operative chemotherapy (median OS 38 vs. 19 months; p = 0.0007). In multivariable analysis, high gC1qR expression was an independent factor for improved OS in patients treated with NAC. In the No-NAC cohort, high gC1qR expression correlated with lower tumor stage. Moreover, the influence of Ki67 and CD4 T-cell infiltration on OS were more pronounced among patients with high gC1qR expression. Conclusion: This is the first description of gC1qR expression in MPM. The data identify gC1qR as a potential new prognostic factor in patients treated with surgery and chemotherapy. © Copyright © 2019 Li, Eguchi, Aly, Chintala, Tan, Zauderer, Dembitzer, Beasley, Ghebrehiwet, Adusumilli and Peerschke.
Keywords:	immunohistochemistry; adult; controlled study; human tissue; aged; major clinical study; overall survival; pathophysiology; postoperative care; chemotherapy; follow up; cd3 antigen; cd8 antigen; ki 67 antigen; transcription factor foxp3; phenotype; gene overexpression; gene expression; cell infiltration; lung resection; cohort analysis; retrospective study; cd20 antigen; tumor recurrence; cd4+ t lymphocyte; pleura mesothelioma; cd4 antigen; tissue microarray; neoadjuvant chemotherapy; decortication; pleurectomy; malignant pleural mesothelioma; cd4 t cell; cd163 antigen; cd68 antigen; tumor invasion; complement system; human; male; female; article; complement component c1q; gc1qr/p32/habp1 (gc1qr)
Journal Title:	Frontiers in Oncology
Volume:	9
ISSN:	2234-943X
Publisher:	Frontiers Media S.A.
Date Published:	2019-10-11
Start Page:	1042
Language:	English
DOI:	10.3389/fonc.2019.01042
PROVIDER:	scopus
PMCID:	PMC6799080
PUBMED:	31681580
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85074268001&doi=10.3389%2ffonc.2019.01042&partnerID=40&md5=4861c374bce3dee64b37e891607b06d5
Notes:	Article -- Export Date: 2 December 2019 -- Source: Scopus

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