Hypothalamic-pituitary disorders in childhood cancer survivors: Prevalence, risk factors and long-term health outcomes Journal Article


Authors: van Iersel, L.; Li, Z.; Srivastava, D. K.; Brinkman, T. M.; Bjornard, K. L.; Wilson, C. L.; Green, D. M.; Merchant, T. E.; Pui, C. H.; Howell, R. M.; Smith, S. A.; Armstrong, G. T.; Hudson, M. M.; Robison, L. L.; Ness, K. K.; Gajjar, A.; Krull, K. R.; Sklar, C. A.; van Santen, H. M.; Chemaitilly, W.
Article Title: Hypothalamic-pituitary disorders in childhood cancer survivors: Prevalence, risk factors and long-term health outcomes
Abstract: CONTEXT: Data on hypothalamic-pituitary (HP) disorders in systematically evaluated childhood cancer survivors are limited. OBJECTIVE: To describe prevalence, risk factors, and associated adverse health outcomes of deficiencies in GH deficiency (GHD), TSH deficiency (TSHD), LH/FSH deficiency (LH/FSHD), and ACTH deficiency (ACTHD), and central precocious puberty (CPP). DESIGN: Retrospective with cross-sectional health outcomes analysis. SETTING: Established cohort; tertiary care center. PATIENTS: Participants (N = 3141; median age, 31.7 years) were followed for a median 24.1 years. MAIN OUTCOME MEASURE: Multivariable logistic regression was used to calculate ORs and 95% CIs for associations among HP disorders, tumor- and treatment-related risk factors, and health outcomes. RESULTS: The estimated prevalence was 40.2% for GHD, 11.1% for TSHD, 10.6% for LH/FSHD, 3.2% for ACTHD, and 0.9% for CPP among participants treated with HP radiotherapy (n = 1089), and 6.2% for GHD, and <1% for other HP disorders without HP radiotherapy. Clinical factors independently associated with HP disorders included HP radiotherapy (at any dose for GHD, TSHD, LH/FSHD, >30 Gy for ACTHD), alkylating agents (GHD, LH/FSHD), intrathecal chemotherapy (GHD), hydrocephalus with shunt placement (GHD, LH/FSHD), seizures (TSHD, ACTHD), and stroke (GHD, TSHD, LH/FSHD, ACTHD). Adverse health outcomes independently associated with HP disorders included short stature (GHD, TSHD), severe bone mineral density deficit (GHD, LH/FSHD), obesity (LH/FSHD), frailty (GHD), impaired physical health-related quality of life (TSHD), sexual dysfunction (LH/FSHD), impaired memory, and processing speed (GHD, TSHD). CONCLUSION: HP radiotherapy, central nervous system injury, and, to a lesser extent, chemotherapy are associated with HP disorders, which are associated with adverse health outcomes. Copyright © 2019 Endocrine Society.
Journal Title: Journal of Clinical Endocrinology and Metabolism
Volume: 104
Issue: 12
ISSN: 0021-972X
Publisher: Oxford University Press  
Date Published: 2019-12-01
Start Page: 6101
End Page: 6115
Language: English
DOI: 10.1210/jc.2019-00834
PUBMED: 31373627
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 2 December 2019 -- Source: Scopus
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MSK Authors
  1. Charles A Sklar
    298 Sklar