Total synthesis of the bacterial diisonitrile chalkophore SF2768 Research Letter
| Authors: | Xu, Y.; Tan, D. S. |
| Title: | Total synthesis of the bacterial diisonitrile chalkophore SF2768 |
| Abstract: | Chalkophores are bacterial natural products that chelate and transport extracellular copper. The diisonitrile natural product SF2768 was first isolated from a Streptomyces species as an antifungal antibiotic and has more recently been characterized as a bacterial chalkophore and potential virulence factor. Herein, we report a modular synthesis of SF2768 and related acyclic analogues, allowing assignment of syn-stereochemistry across the central lactol ring. The copper-binding properties of these diisonitriles have also been studied. © 2019 American Chemical Society. |
| Keywords: | synthesis; stereochemistry; article |
| Journal Title: | Organic Letters |
| Volume: | 21 |
| Issue: | 21 |
| ISSN: | 1523-7060 |
| Publisher: | American Chemical Society |
| Date Published: | 2019-11-01 |
| Start Page: | 8731 |
| End Page: | 8735 |
| Language: | English |
| DOI: | 10.1021/acs.orglett.9b03348 |
| PUBMED: | 31633364 |
| PROVIDER: | scopus |
| PMCID: | PMC6905096 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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