Radical prostatectomy for high-risk prostate cancer Journal Article
| Authors: | Yossepowitch, O.; Eastham, J. A. |
| Article Title: | Radical prostatectomy for high-risk prostate cancer |
| Abstract: | Objectives: Consensus recommendations for the identification and treatment of men whose apparent organ confined prostate cancer has high risk features are lacking. Despite ongoing refinements in surgical technique and improvements in morbidity and functional outcomes, the tradition of steering high-risk patients away from radical prostatectomy (RP) remains steadfast. Methods: We performed a medical literature search in English using MEDLINE®/PubMed® that addressed high risk prostate cancer. We analyzed the literature with respect to the historical evolution of this concept, current risk stratification schemes and treatment guidelines and related short and long term outcomes following RP. Results: Contemporary evidence suggest that patients classified with high-risk prostate cancer by commonly used definitions do not have a uniformly poor prognosis after RP. Many cancers categorized clinically as high risk are actually pathologically confined to the prostate, and most men with such cancers who undergo RP are alive and free of additional therapy long after surgery. RP in the high-risk setting appears to be associated with a similar morbidity as in lower-risk patients. Conclusion: Men with clinically localized high-risk prostate cancer should not be categorically disqualified from local definitive therapy with RP. With careful attention to surgical technique, cancer control rates should improve further, and adverse effects on quality of life after RP should continue to decrease. © Springer-Verlag 2008. |
| Keywords: | disease-free survival; survival rate; cancer staging; methodology; neoplasm staging; metastasis; morbidity; risk factors; pathology; risk factor; biopsy; prostatic neoplasms; prostatectomy; prostate tumor; risk stratification |
| Journal Title: | World Journal of Urology |
| Volume: | 26 |
| Issue: | 3 |
| ISSN: | 0724-4983 |
| Publisher: | Springer |
| Date Published: | 2008-06-01 |
| Start Page: | 219 |
| End Page: | 224 |
| Language: | English |
| DOI: | 10.1007/s00345-008-0247-2 |
| PUBMED: | 18335221 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 5" - "Export Date: 17 November 2011" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
-
537Eastham -
33Yossepowitch
Related MSK Work