High-dose chemotherapy with autologous stem cell rescue in stage IIIB inflammatory breast cancer Journal Article
| Authors: | Yalamanchili, K.; Lalmuanpuii, J.; Waheed, F.; Farjami, S.; Kancherla, R. A. M.; Qureshi, Z.; Hoang, A.; Khaled, Y.; Lake, D.; Puccio, C.; Chun, H. G.; Seiter, K.; Ahmed, T. |
| Article Title: | High-dose chemotherapy with autologous stem cell rescue in stage IIIB inflammatory breast cancer |
| Abstract: | Background: Despite the advances in breast cancer care, inflammatory breast cancer (IBC) has a poor prognosis. The purpose of this study was to determine the efficacy of high-dose chemotherapy (HDCT) with thiotepa, mitoxantrone and carboplatin (TMJ regimen) in women with TNM stage IIIB IBC. Patients and Methods: Between 1991 and 1998, twenty-eight patients with stage IIIB IBC underwent an autologous stem cell transplant after undergoing chemotherapy, surgery and/or radiation. Stem cells were collected from the bone marrow and periphery after mobilization with growth factors. Patients received thiotepa 250 mg/m2 once daily i.v. for 3 days, mitoxantrone 40 mg/m2 for 1 day and carboplatin 333 mg/m2 once daily i.v. for 3 days as the conditioning regimen for the HDCT. Radiation therapy and tamoxifen was offered to patients post HDCT if appropriate. Progression-free survival and overall survival was assessed over a 15-year period. Results: At the time of last follow-up in May, 2007, sixteen patients had relapsed. The median overall survival was 49.5 months. The median progression free survival was 40 months. There were no transplant-related deaths. Mucositis and infections were the major side-effects. These results show that HDCT with the TMJ regimen is safe and effective in patients with stage IIIB IBC. |
| Keywords: | adult; cancer chemotherapy; cancer survival; controlled study; middle aged; doxorubicin; fluorouracil; cancer risk; drug efficacy; drug safety; paclitaxel; cancer radiotherapy; neoadjuvant therapy; chemotherapy; cancer staging; drug megadose; follow-up studies; antineoplastic agent; neoplasm staging; carboplatin; infection; breast cancer; mucosa inflammation; antineoplastic combined chemotherapy protocols; inflammation; stem cell transplant; cyclophosphamide; stem cell transplantation; dose-response relationship, drug; breast neoplasms; thiotepa; stem cell; docetaxel; myelodysplastic syndrome; mitoxantrone; tamoxifen; hyperbilirubinemia; inflammatory breast cancer; autologous |
| Journal Title: | Anticancer Research |
| Volume: | 28 |
| Issue: | 5 B |
| ISSN: | 0250-7005 |
| Publisher: | International Institute of Anticancer Research |
| Date Published: | 2008-09-01 |
| Start Page: | 3139 |
| End Page: | 3142 |
| Language: | English |
| PUBMED: | 19031971 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 17 November 2011" - "CODEN: ANTRD" - "Source: Scopus" |
