Synthesis and cytotoxic evaluation of some cribrostatin-ecteinascidin analogues Journal Article
| Authors: | Wright, B. J. D.; Chan, C.; Danishefsky, S. J. |
| Article Title: | Synthesis and cytotoxic evaluation of some cribrostatin-ecteinascidin analogues |
| Abstract: | Analogues of cribrostatin IV (1) and the potent antineoplastic agent ecteinascidin 743 (2) have been synthesized. The cytotoxic activity of these compounds (5, 14, 20) has been determined, and the cyanoamine-cribrostatin analogue (14) exhibits a 20-fold improvement with regard to the natural product 1. © 2008 American Chemical Society and American Society of Pharmacognosy. |
| Keywords: | controlled study; unclassified drug; human cell; cytotoxicity; drug screening assays, antitumor; drug synthesis; structure-activity relationship; amine; drug mechanism; antineoplastic agents, alkylating; molecular structure; trabectedin; dioxoles; isoquinolines; cribrostatin; cyanoamine; tetrahydroisoquinolines |
| Journal Title: | Journal of Natural Products |
| Volume: | 71 |
| Issue: | 3 |
| ISSN: | 0163-3864 |
| Publisher: | American Chemical Society |
| Date Published: | 2008-03-01 |
| Start Page: | 409 |
| End Page: | 414 |
| Language: | English |
| DOI: | 10.1021/np800022x |
| PUBMED: | 18278868 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 12" - "Export Date: 17 November 2011" - "CODEN: JNPRD" - "Source: Scopus" |
