Clinical impact of molecular analysis on thyroid cancer management Journal Article
| Authors: | Wreesmann, V. B.; Singh, B. |
| Article Title: | Clinical impact of molecular analysis on thyroid cancer management |
| Abstract: | Thyroid cancer constitutes a progressive continuum of disease ranging from indolent well-differentiated carcinomas to aggressive poorly differentiated carcinomas and universally fatal anaplastic carcinomas. The wide divergence in clinical behavior is poorly predicted for by current clinicopathological factors. Moreover, therapeutic armentarium against aggressive thyroid cancers remains limited. Recent studies have identified a range of molecular alterations in thyroid cancers. Clinical implications of the molecular alterations include their utility in diagnostic evaluation, staging and targeted treatment. Continued molecular analysis of thyroid cancers promises to increase our understanding of its biologic behavior and is expected to have further impact on its clinical management. © 2008 Elsevier Inc. All rights reserved. |
| Keywords: | signal transduction; protein kinase b; unclassified drug; mutation; lenalidomide; clinical trial; review; sorafenib; sunitinib; diarrhea; monotherapy; nonhuman; paclitaxel; cancer staging; cancer diagnosis; genetic analysis; gene targeting; imatinib; diagnostic procedure; carboplatin; bortezomib; gene expression; qt prolongation; tumor differentiation; enzyme activation; pathology; protein p53; docetaxel; irinotecan; rash; genome analysis; radioactive iodine; biological activity; vandetanib; ras protein; thyroid cancer; thyroid neoplasms; molecular biology; axitinib; genetic screening; beta catenin; peroxisome proliferator activated receptor gamma; rosiglitazone; thyroid papillary carcinoma; romidepsin; b raf kinase; oncogene ras; anaplastic carcinoma; 2 morpholino 8 phenylchromone; genes, p53; onyx 015; thyroid follicular carcinoma; molecular therapy; protein kinase b inhibitor; pyrazolopyrimidine derivative; growth factor receptor; combretastatin; kp 3721; neurotrophic tyrosine kinase receptor type 1 |
| Journal Title: | Surgical Oncology Clinics of North America |
| Volume: | 17 |
| Issue: | 1 |
| ISSN: | 1055-3207 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2008-01-01 |
| Start Page: | 1 |
| End Page: | 35 |
| Language: | English |
| DOI: | 10.1016/j.soc.2007.10.013 |
| PUBMED: | 18177798 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 5" - "Export Date: 17 November 2011" - "CODEN: SOCAF" - "Source: Scopus" |
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