Migratory neighbors and distant invaders: Tumor-associated niche cells Journal Article
| Authors: | Wels, J.; Kaplan, R. N.; Rafii, S.; Lyden, D. |
| Article Title: | Migratory neighbors and distant invaders: Tumor-associated niche cells |
| Abstract: | The cancer environment is comprised of tumor cells as well as a wide network of stromal and vascular cells participating in the cellular and molecular events necessary for invasion and metastasis. Tumor secretory factors can activate the migration of host cells, both near to and far from the primary tumor site, as well as promote the exodus of cells to distant tissues. Thus, the migration of stromal cells and tumor cells among specialized microenvironments takes place throughout tumor and metastatic progression, providing evidence for the systemic nature of a malignancy. Investigations of the tumor-stromal and stromal-stromal cross-talk involved in cellular migration in cancer may lead to the design of novel therapeutic strategies. © 2008 by Cold Spring Harbor Laboratory Press. |
| Keywords: | signal transduction; platelet derived growth factor; protein expression; review; nonhuman; neoplasms; tumor associated leukocyte; metastasis; thrombocyte; interleukin 10; interleukin 8; inflammation; vasculotropin receptor 2; angiogenesis; neovascularization, pathologic; stem cell; cancer invasion; extracellular matrix; endothelial cells; chemokine; matrix metalloproteinase; vasculotropin a; tumor cell; neoplasm metastasis; cell migration; fibroblast; cell movement; stroma; mesenchymal stem cell; cytokine production; neoplasm invasiveness; bone marrow cell; microenvironment; proteinase; placental growth factor; stromal cells; cell interaction; growth factor; granulocyte colony stimulating factor; cell motility; invasion; migration; vasculotropin receptor 1; cxcl1 chemokine; colony stimulating factor 1; angiopoietin 2; tumor microenvironment; pericyte; calgranulin a; calvasculin; angiopoietin 1; rantes; calgranulin b |
| Journal Title: | Genes and Development |
| Volume: | 22 |
| Issue: | 5 |
| ISSN: | 0890-9369 |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Date Published: | 2008-03-01 |
| Start Page: | 559 |
| End Page: | 574 |
| Language: | English |
| DOI: | 10.1101/gad.1636908 |
| PUBMED: | 18316475 |
| PROVIDER: | scopus |
| PMCID: | PMC2731657 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 73" - "Export Date: 17 November 2011" - "CODEN: GEDEE" - "Source: Scopus" |
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