Feasibility of using limited-population-based arterial input function for pharmacokinetic modeling of osteosarcoma dynamic contrast-enhanced MRI data Journal Article

   

Authors:	Wang, Y.; Huang, W.; Panicek, D. M.; Schwartz, L. H.; Koutcher, J. A.
Article Title:	Feasibility of using limited-population-based arterial input function for pharmacokinetic modeling of osteosarcoma dynamic contrast-enhanced MRI data
Abstract:	For clinical dynamic contrast-enhanced (DCE) MRI studies, it is often not possible to obtain reliable arterial input function (AIF) in each measurement. Thus, it is important to find a representative AIF for pharmacokinetic modeling of DCE-MRI data when individual AIF (Ind-AIF) measurements are not available. A total of 16 patients with osteosarcomas in the lower extremity (knee region) underwent multislice DCE-MRI. Reliable Ind-AIFs were obtained in five patients with a contrast injection rate of 2 cc/s and another five patients with a 1 cc/s injection rate. Average AIF (Avg-AIF) for each injection rate was constructed from the corresponding five Ind-AIFs. For each injection rate there are no statistically significant differences between pharmacokinetic parameters of the five patients derived with Ind-AIFs and Avg-AIF. There are no statistically significant changes in pharmacokinetic parameters of the 16 patients when the two Avg-AIFs were applied in kinetic modeling. The results suggest that it is feasible, as well as practical, to use a limited-population-based Avg-AIF for pharmacokinetic modeling of osteosarcoma DCE-MRI data. Further validation with a larger population and multiple regions is desirable. © 2008 Wiley-Liss, Inc.
Keywords:	osteosarcoma; adolescent; adult; child; clinical article; school child; bone neoplasms; nuclear magnetic resonance imaging; magnetic resonance imaging; image interpretation, computer-assisted; mathematical model; population research; feasibility study; feasibility studies; contrast enhancement; contrast medium; contrast media; reliability; gadolinium dtpa; dynamic contrast-enhanced mri; arterial input function; k trans; pharmakinetic modeling
Journal Title:	Magnetic Resonance in Medicine
Volume:	59
Issue:	5
ISSN:	0740-3194
Publisher:	John Wiley & Sons
Date Published:	2008-05-01
Start Page:	1183
End Page:	1189
Language:	English
DOI:	10.1002/mrm.21432
PUBMED:	18429032
PROVIDER:	scopus
PMCID:	PMC2782487
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-42549169689&partnerID=40&md5=c8da52d499260edd354329a0ce025a54
Notes:	--- - "Cited By (since 1996): 16" - "Export Date: 17 November 2011" - "CODEN: MRMEE" - "Source: Scopus"

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