Impact of attenuation and scatter correction in estimating tumor hypoxia-related kinetic parameters for FMISO dynamic animal-PET imaging Conference Paper
| Authors: | Wang, W.; Chen, M.; Carlin, S.; Oehler, C.; Zanzonico, P.; Humm, J. |
| Title: | Impact of attenuation and scatter correction in estimating tumor hypoxia-related kinetic parameters for FMISO dynamic animal-PET imaging |
| Conference Title: | 2008 IEEE Nuclear Science Symposium Conference Record |
| Abstract: | Tumor hypoxia promotes tumor progression and reduces the efficacy of radiation and chemotherapy. A potentially important non-invasive hypoxia imaging technique is positronemission- tomography (PET) with the radiotracer 18Ffluoromisonidazole (FMISO). FMISO binds to macromolecules and is trapped within cells in the absence of oxygen. The time course of this process may be imaged with dynamic PET, and a pharmacokinetic compartmental model has been used to evaluate the rate constants between different compartments in a tumor. In our Small-Animal-Imaging Facility, most animal-PET data are reconstructed without attenuation-correction (AC) or scattercorrection (SC). We have investigated how these correction factors affect the rate constant's estimation in hypoxic tumor. A 4D dynamic digital PET phantom is created to simulate a 300gram rat with a 5-gram xenografted subcutaneous human colorectal adenocarcinoma tumor, injected with a 2-mCi FMISO bolus via the tail vein, and imaged on our Focus-120 micro-PET for 90 minutes. The 4D dynamic image data is then forward projected to simulate the 4D dynamic sinogram. FORE+2DOSEM and FORE+FBP reconstruction protocols are used with and without AC&SC. The reconstructed dynamic images are then analyzed with the pharmacokinetic compartmental model and the estimated kinetic parameters are compared with the original one. is found that the image-based plasma input function plays an important role in kinetic analysis. Present PET technology could not fully recover the sharp peak of the plasma input function, and makes estimated kinetic parameters differ from the true ones by 5.7-8.8% with ACSC, and 10.4-12.60/0 without ACSC. ©2008 IEEE. |
| Keywords: | chemotherapy; plasmas; oxygen; tomography; tumors; pet imaging; kinetic analysis; rate constants; tumor hypoxia; pharmacokinetics; compartmental model; dynamic pet; image-based; input functions; pet data; kinetic parameters; colorectal adenocarcinoma; non-invasive; time course; correction factors; dynamic images; pet technology; scatter-correction; sinogram; small-animal; tail veins; tumor progressions; supramolecular chemistry |
| Journal Title | IEEE Nuclear Science Symposium Conference Record |
| Conference Dates: | 2008 Oct 19-25 |
| Conference Location: | Dresden, Germany |
| ISBN: | 1095-7863 |
| Publisher: | IEEE |
| Date Published: | 2008-01-01 |
| Start Page: | 5234 |
| End Page: | 5239 |
| Language: | English |
| DOI: | 10.1109/NSSMIC.2008.4774415 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - IEEE Nuclear Science Symposium Conference Record - IEEE Nucl. Sci. Symp. Conf. Rec. - "Conference code: 76975" - "Cited By (since 1996): 1" - "Export Date: 17 November 2011" - "Art. No.: 4774415" - "CODEN: 85OQA" - "Sponsors: Nuclear and Plasma Sci. Soc. Inst. Electr.and Electron.Eng.; IEEE Nuclear and Plasma Sciences Society" - 19 October 2008 through 25 October 2008 - "Source: Scopus" |
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