Oxo-ester mediated native chemical ligation: Concept and applications Journal Article

   


Authors: Wan, Q.; Chen, J.; Yuan, Y.; Danishefsky, S. J.
Article Title: Oxo-ester mediated native chemical ligation: Concept and applications
Abstract: A direct oxo-ester peptide ligation method has been developed. Through the use of an activated C-terminal para nitrophenyl ester (1), it is possible to achieve direct cysteine ligations (1 + 2 → 4). Peptide substrates incorporating bulky C-terminal amino acids (1) can be accommodated with high reaction efficiency. Copyright © 2008 American Chemical Society.
Keywords: chemical analysis; erythropoietin; carboxy terminal sequence; amino terminal sequence; protein synthesis; nuclear magnetic resonance spectroscopy; models, molecular; molecular structure; hydrolysis; glycoprotein; glycopeptide; esters; amino acid analysis; chemical ligation; glycine derivative; penicillamine; aminolysis
Journal Title: Journal of the American Chemical Society
Volume: 130
Issue: 47
ISSN: 0002-7863
Publisher: American Chemical Society  
Date Published: 2008-11-26
Start Page: 15814
End Page: 15816
Language: English
DOI: 10.1021/ja804993y
PUBMED: 18855357
PROVIDER: scopus
PMCID: PMC2645925
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-56749092136&partnerID=40&md5=f7272f7537fefaaef05f70d3354eb564
Notes: --- - "Cited By (since 1996): 14" - "Export Date: 17 November 2011" - "CODEN: JACSA" - "Source: Scopus"
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MSK Authors
  1. Qian Wan
    23 Wan
  2. Yu Yuan
    11 Yuan
  3. Jin Chen
    5 Chen
  4. Samuel J Danishefsky
    539 Danishefsky
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