Co-existent pilocytic astrocytoma with acute B-cell leukemia within the cerebellum Journal Article
| Authors: | Hickman, R.; Leeman-Neill, R.; Rosenblum, M.; Anderson, R.; Goldman, J. |
| Article Title: | Co-existent pilocytic astrocytoma with acute B-cell leukemia within the cerebellum |
| Abstract: | Pilocytic astrocytomas are the commonest childhood brain tumor. They are typically benign and usually are solitary neoplasms. To our knowledge, only one report of a pilocytic astrocytoma with leukemia has been previously issued. We herein describe the first case with documented histopathology of a 2-year-old boy who had a cerebellar pilocytic astrocytoma co-localized with an acute B-lymphoblastic leukemia. We speculate that chemotactic migration of leukemic cells to the pilocytic astrocytoma may be partly mediated through vascular endothelial growth factor (VEGF) and VEGF receptors. © 2019 Japanese Society of Neuropathology |
| Keywords: | immunohistochemistry; child; clinical article; human tissue; preschool child; leukemia; human cell; case report; flow cytometry; nuclear magnetic resonance imaging; ki 67 antigen; cd34 antigen; anemia; thrombocytopenia; brain injury; hemoglobin; hemoglobin blood level; vasculotropin receptor 2; angiogenesis; tissue section; chemotaxis; bone marrow biopsy; vasculotropin a; immunophenotyping; eosin; hematoxylin; leukocyte count; right hemisphere; erythrocyte transfusion; brain surgery; formaldehyde; thrombocyte transfusion; platelet count; hematocrit; b cell leukemia; paraffin embedding; cerebellum tumor; falling; pilocytic astrocytoma; cd34 antibody; human; male; priority journal; article; preoperative complication |
| Journal Title: | Neuropathology |
| Volume: | 39 |
| Issue: | 5 |
| ISSN: | 0919-6544 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2019-10-01 |
| Start Page: | 394 |
| End Page: | 397 |
| Language: | English |
| DOI: | 10.1111/neup.12587 |
| PUBMED: | 31408921 |
| PROVIDER: | scopus |
| PMCID: | PMC7359741 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 November 2019 -- Source: Scopus |
