Timing of surgery and adjuvant radiation therapy for sinonasal malignancies: Effect of surgical approach Journal Article
| Authors: | Xiao, R.; Joshi, R. R.; Husain, Q.; Cracchiolo, J. R.; Lee, N.; Tsai, J.; Yu, Y.; Chen, L.; Kang, J. J.; McBride, S.; Riaz, N.; Roman, B. R.; Ganly, I.; Tabar, V.; Gray, S. T.; Cohen, M. A. |
| Article Title: | Timing of surgery and adjuvant radiation therapy for sinonasal malignancies: Effect of surgical approach |
| Abstract: | Background: Timely postoperative radiation therapy (RT) within 50 days of surgery for head and neck cancers provides a survival advantage. Methods: Using the National Cancer Database, we performed a propensity score-matched analysis comparing patients undergoing open or endoscopic surgery for squamous cell carcinoma (SCC) of the nasal cavity and paranasal sinuses from 2010 to 2015. Results: Among 168 pairs, patients undergoing endoscopic surgery had shorter time to surgery (24.2 vs 36.7 days, P <.001) and shorter postoperative time to RT (PTTR, 51.2 vs 58.4 days, P =.02). On multivariable linear regression, endoscopic surgery predicted shorter PTTR (β = −7.6, P =.01). Using the Kaplan-Meier method, patients in the longest PTTR quartile had decreased overall survival (OS; Q1 vs Q4, 3-year OS 76.5% vs 53.3%, P =.007), a durable finding when adjusted for covariates (Q1 vs Q4, HR 0.50, P =.008). Conclusions: Patients undergoing endoscopic surgery for sinonasal SCC experience shorter PTTR. Shorter PTTR is associated with extended OS. © 2019 Wiley Periodicals, Inc. |
| Keywords: | overall survival; national cancer database; sinonasal squamous cell carcinoma; time to surgery; postoperative time to radiation therapy |
| Journal Title: | Head & Neck |
| Volume: | 41 |
| Issue: | 10 |
| ISSN: | 1043-3074 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 2019-10-01 |
| Start Page: | 3551 |
| End Page: | 3563 |
| Language: | English |
| DOI: | 10.1002/hed.25873 |
| PUBMED: | 31294897 |
| PROVIDER: | scopus |
| PMCID: | PMC6742559 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 November 2019 -- Source: Scopus |
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