Hereditary diffuse gastric cancer: Cancer risk and the personal cost of preventive surgery Journal Article


Authors: Kaurah, P.; Talhouk, A.; MacMillan, A.; Lewis, I.; Chelcun-Schreiber, K.; Yoon, S. S.; Huntsman, D.
Article Title: Hereditary diffuse gastric cancer: Cancer risk and the personal cost of preventive surgery
Abstract: Germline CDH1 mutation carriers are at risk for early-onset diffuse gastric cancer (DGC) and female carriers have an additional risk of lobular breast cancer. The reported literature GC risk of 70% has led to the recommendation for germline mutation carriers to undergo prophylactic total gastrectomy (PTG). The objective of this research was to examine post-surgical clinical outcomes and to identify which of the domains/symptoms from the European Organisation for Research and Treatment of Cancer QOL Questionnaire (EORTC QLQ-C30) were determinants of overall quality of life (QOL) in individuals undergoing PTG. Participants were recruited through multiple sources. Postsurgical clinical outcomes were obtained from hospital records. Participants completed validated questionnaires measuring generic and condition specific QOL (PROMIS, EORTC and SF 36v.II) at a single point in time. The mean QOL in this cohort was 70.6 (SD = 25.6), which is better than reference values from the general populations in USA and Canada Role and social function plus the symptoms anxiety, pain, taste, dyspnea and diarrhea were significant predictor variables for QOL (p < 0.05). Although this study reveals good overall QOL for individuals after PTG, attention should be given to managing symptoms as part of long term care to further enhance QOL. The function/symptom scores were associated with worse overall health and global health status and thus may mark a real need for more attentive post-surgical care. © 2019, Springer Nature B.V.
Keywords: adult; patient satisfaction; gene mutation; major clinical study; cancer risk; diarrhea; cancer prevention; quality of life; pain; lung disease; heterozygote; medical record review; retrospective study; uvomorulin; dyspnea; lung embolism; postoperative complication; social status; health care cost; multicenter study; urinary tract infection; taste disorder; predictor variable; stomach cancer; anxiety; iron deficiency; wound infection; ileus; small intestine obstruction; anastomosis leakage; duodenum obstruction; clinical outcome; bile reflux; total stomach resection; patient-reported outcome; germline mutation; clinical outcomes; diffuse gastric cancer; human; male; female; priority journal; article; hereditary tumor syndrome; predictor variables; total prophylactic gastrectomy; european organization for research and treatment of cancer quality of life questionnaire core 30; pulmonary effusion
Journal Title: Familial Cancer
Volume: 18
Issue: 4
ISSN: 1389-9600
Publisher: Springer  
Date Published: 2019-10-01
Start Page: 429
End Page: 438
Language: English
DOI: 10.1007/s10689-019-00133-9
PUBMED: 31273560
PROVIDER: scopus
DOI/URL:
Notes: Source: Scopus
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  1. Sam Yoon
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