The classic: Integration of deoxyribonucleic acid specific for rous sarcoma virus after infection of permissive and nonpermissive hosts (RNA tumor viruses/reassociation kinetics/duck cells) Journal Article
| Authors: | Varmus, H. E.; Vogt, P. K.; Bishop, J. M.; Healey, J. H. |
| Article Title: | The classic: Integration of deoxyribonucleic acid specific for rous sarcoma virus after infection of permissive and nonpermissive hosts (RNA tumor viruses/reassociation kinetics/duck cells) |
| Abstract: | A relatively simple but stringent technique was developed to detect the integration of virus-specific DNA into the genomes of higher organisms. In both permissive (duck) and nonpermissive (mammalian) cells which normally contain no nucleotide sequences specific for Rous sarcoma virus, transformation by the virus results in the appearance of DNA specific for Rous sarcoma virus covalently integrated into strands of host-cell DNA containing reiterated sequences. Early after infection of mouse or duck cells by Rous sarcoma virus, unintegrated DNA specific for the virus can be demonstrated. © 2008 The Association of Bone and Joint Surgeons. |
| Keywords: | genetics; nonhuman; conference paper; animal cell; animal; animals; history, 21st century; bird disease; cell transformation, neoplastic; history; history, 20th century; cancer center; biosynthesis; dna; cell transformation; medical research; medical specialist; physician; dna, viral; tumor virus infections; virus infection; virus replication; isolation and purification; virus genome; dna determination; retrovirus infection; orthopedic surgery; retroviridae infections; virus dna; hemoglobinopathy; portraits as topic; art; rna tumor virus; rous sarcoma oncovirus; virus dna cell dna interaction; virus transformation; duck; ducks; rous sarcoma virus; sarcoma, avian; virus integration |
| Journal Title: | Clinical Orthopaedics and Related Research |
| Volume: | 466 |
| Issue: | 9 |
| ISSN: | 0009-921X |
| Publisher: | Springer |
| Date Published: | 2008-09-01 |
| Start Page: | 2031 |
| End Page: | 2038 |
| Language: | English |
| DOI: | 10.1007/s11999-008-0355-8 |
| PUBMED: | 18597148 |
| PROVIDER: | scopus |
| PMCID: | PMC2493013 |
| DOI/URL: | |
| Notes: | Erratum/Corrigendum issued, see DOI: 10.1007/s11999-009-0905-8 -- "Export Date: 17 November 2011" - "CODEN: CORTB" - "Source: Scopus" |
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