Polysomy is associated with poor outcome in 1p/19q codeleted oligodendroglial tumors Journal Article
| Authors: | Chen, H.; Thomas, C.; Munoz, F. A.; Alexandrescu, S.; Horbinski, C. M.; Olar, A.; McGuone, D.; Camelo-Piragua, S.; Wang, L.; Pentsova, E.; Phillips, J.; Aldape, K.; Chen, W.; Iafrate, A. J.; Chi, A. S.; Zagzag, D.; Golfinos, J. G.; Placantonakis, D. G.; Rosenblum, M.; Ohman-Strickland, P.; Hameed, M.; Snuderl, M. |
| Article Title: | Polysomy is associated with poor outcome in 1p/19q codeleted oligodendroglial tumors |
| Abstract: | Background: Chromosomal instability is associated with earlier progression in isocitrate dehydrogenase (IDH)-mutated astrocytomas. Here we evaluated the prognostic significance of polysomy in gliomas tested for 1p/19q status. Methods: We analyzed 412 histologic oligodendroglial tumors with use of 1p/19q testing at 8 institutions from 1996 to 2013; fluorescence in situ hybridization (FISH) for 1p/19q was performed. Polysomy was defined as more than two 1q and 19p signals in cells. Tumors were divided into groups on the basis of their 1p/19q status and polysomy and were compared for progression-free survival (PFS) and overall survival (OS). Results: In our cohort, 333 tumors (81%) had 1p/19q loss; of these, 195 (59%) had concurrent polysomy and 138 (41%) lacked polysomy, 79 (19%) had 1p/19q maintenance; of these, 30 (38%) had concurrent polysomy and 49 (62%) lacked polysomy. In agreement with prior studies, the group with 1p/19q loss had significantly better PFS and OS than did the group with 1p/19q maintenance (P < 0.0001 each). Patients with 1p/19q loss and polysomy showed significantly shorter PFS survival than patients with 1p/19q codeletion only (P < 0.0001), but longer PFS and OS than patients with 1p/19q maintenance (P < 0.01 and P < 0.0001). There was no difference in survival between tumors with >30% polysomic cells and those with <30% polysomic cells. Polysomy had no prognostic significance on PFS or OS in patients with 1p/19q maintenance. Conclusions: The presence of polysomy in oligodendroglial tumors with codeletion of 1p/19q predicts early recurrence and short survival in patients with 1p/19q codeleted tumors. © 2019 The Author(s). Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. |
| Keywords: | glioma; oligodendroglioma; polysomy; 1p/19q codeletion |
| Journal Title: | Neuro-Oncology |
| Volume: | 21 |
| Issue: | 9 |
| ISSN: | 1522-8517 |
| Publisher: | Oxford University Press |
| Date Published: | 2019-09-01 |
| Start Page: | 1164 |
| End Page: | 1174 |
| Language: | English |
| DOI: | 10.1093/neuonc/noz098 |
| PUBMED: | 31140557 |
| PROVIDER: | scopus |
| PMCID: | PMC7571489 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 November 2019 -- Source: Scopus |
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