CSF-1 controls cerebellar microglia and is required for motor function and social interaction Journal Article

   

Authors:	Kana, V.; Desland, F. A.; Casanova-Acebes, M.; Ayata, P.; Badimon, A.; Nabel, E.; Yamamuro, K.; Sneeboer, M.; Tan, I. L.; Flanigan, M. E.; Rose, S. A.; Chang, C.; Leader, A.; Le Bourhis, H.; Sweet, E. S.; Tung, N.; Wroblewska, A.; Lavin, Y.; See, P.; Baccarini, A.; Ginhoux, F.; Chitu, V.; Stanley, E. R.; Russo, S. J.; Yue, Z.; Brown, B. D.; Joyner, A. L.; De Witte, L. D.; Morishita, H.; Schaefer, A.; Merad, M.
Article Title:	CSF-1 controls cerebellar microglia and is required for motor function and social interaction
Abstract:	Microglia, the brain resident macrophages, critically shape forebrain neuronal circuits. However, their precise function in the cerebellum is unknown. Here we show that human and mouse cerebellar microglia express a unique molecular program distinct from forebrain microglia. Cerebellar microglial identity was driven by the CSF-1R ligand CSF-1, independently of the alternate CSF-1R ligand, IL-34. Accordingly, CSF-1 depletion from Nestin+ cells led to severe depletion and transcriptional alterations of cerebellar microglia, while microglia in the forebrain remained intact. Strikingly, CSF-1 deficiency and alteration of cerebellar microglia were associated with reduced Purkinje cells, altered neuronal function, and defects in motor learning and social novelty interactions. These findings reveal a novel CSF-1-CSF-1R signaling-mediated mechanism that contributes to motor function and social behavior. © 2019 Kana et al.
Journal Title:	Journal of Experimental Medicine
Volume:	216
Issue:	10
ISSN:	0022-1007
Publisher:	Rockefeller University Press
Date Published:	2019-10-01
Start Page:	2265
End Page:	2281
Language:	English
DOI:	10.1084/jem.20182037
PUBMED:	31350310
PROVIDER:	scopus
PMCID:	PMC6781012
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85072983559&doi=10.1084%2fjem.20182037&partnerID=40&md5=1e1a92a0a6904045c67c6dba2168b42f
Notes:	Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/155299