The emerging role of anti-angiogenic strategies in hematological malignancies Journal Article
| Authors: | Bompais-Vincent, H.; Vincent, L. |
| Article Title: | The emerging role of anti-angiogenic strategies in hematological malignancies |
| Abstract: | Angiogenesis is defined as the formation of new capillaries from preexisting blood vessels and plays an important role in the progression of solid tumors. Recently, the role of angiogenesis in growth and survival of neoplastic cells of the hematopoietic system has recently been recognized, and provides a rationale for novel therapeutic approaches to hematological malignancy. Overexpression of angiogenic factors in particular VEGF-A and FGF2 in most hematologic malignancies may explain the increased angiogenesis found in these malignancies and correlate with poor prognosis as well as decreased overall survival. This review summarizes the literature concerning the relationship between angiogenesis and disease progression in several hematological malignancies and the recent advances in anti-angiogenesis in these diseases. This review also describes the most important active substances, preclinical and clinical data, and future perspectives. |
| Keywords: | myelofibrosis; overall survival; lenalidomide; thalidomide; disease course; review; sorafenib; bevacizumab; sunitinib; cancer combination chemotherapy; cytarabine; colorectal cancer; bortezomib; multiple myeloma; cell growth; cyclophosphamide; dexamethasone; chronic myeloid leukemia; angiogenesis; hodgkin disease; fibroblast growth factor 2; arsenic trioxide; hematologic malignancy; myelodysplastic syndrome; celecoxib; anti-angiogenic strategies; hematologic malignancies; receptor tyrosine kinase; vascular endothelial growth factor; 2 [[2 [[2 [(2 amino 3 mercaptopropyl)amino] 3 methylpentyl]oxy] 1 oxo 3 phenylpropyl]amino] 4 (methylsulfonyl)butanoic acid isopropyl ester; ciprofloxacin; combretastatin a4 phosphate; daunorubicin; etanercept; matrix metalloproteinase; pentoxifylline; protein farnesyltransferase inhibitor; semaxanib; tipifarnib; tyrosine kinase receptor; vasculotropin a; acute myeloblastic leukemia; antiangiogenic therapy; hematopoietic system; promyelocytic leukemia; tumor cell |
| Journal Title: | Hématologie |
| Volume: | 15 |
| Issue: | 1 |
| ISSN: | 1264-7527 |
| Publisher: | John Libbey Eurotext |
| Date Published: | 2009-01-01 |
| Start Page: | 36 |
| End Page: | 44 |
| Language: | French |
| DOI: | 10.1684/hma.2009.0311 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 30 November 2010" - "CODEN: HEMAF" - "Source: Scopus" |
