Extracellular sequestration and release of fibroblast growth factor: A regulatory mechanism? Journal Article
| Authors: | Vlodavsky, I.; Bar-Shavit, R.; Ishar-Michael, R.; Bashkin, P.; Fuks, Z. |
| Article Title: | Extracellular sequestration and release of fibroblast growth factor: A regulatory mechanism? |
| Abstract: | Basic fibroblast growth factor, (bFGF), promotes the formation of new blood capillaries and is sequestered and protected by binding to heparan sulfate (HS), both on the cell surface and in the extracellular matrix. Release of HS-bound bFGF by heparin-like molecules and HS-degrading enzymes (i.e., heparanase) provides a novel mechanism for regulation of the growth of capillary blood vessels in normal and pathological situations. The extra-cellular matrix also serves as a storage depot for other growth factors and enzymes. © 1991. |
| Keywords: | conference paper; capillary; extracellular matrix; fibroblast growth factor 2; heparin; fibroblast growth factor; heparan sulfate; glycoside hydrolases; heparanase; capillaries; proteoglycans; priority journal; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; support, u.s. gov't, non-p.h.s. |
| Journal Title: | Trends in Biochemical Sciences |
| Volume: | 16 |
| Issue: | 7 |
| ISSN: | 0968-0004 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1991-07-01 |
| Start Page: | 268 |
| End Page: | 271 |
| Language: | English |
| DOI: | 10.1016/0968-0004(91)90102-2 |
| PUBMED: | 1926336 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
