Ganglioside antigens expressed by human cancer cells Journal Article
| Authors: | Ritter, G.; Livingston, P. O. |
| Article Title: | Ganglioside antigens expressed by human cancer cells |
| Abstract: | Gangliosides are normal cell surface components of all animal cells. Altered ganglioside biosynthesis during malignant transformation results in expression of a qualitatively and quantitatively different ganglioside profile in many tumors. While their physiological function is largely unclear, gangliosides expressed by cancer cells, e.g. GD3, GD2 and GM2 in malignant melanoma, have proven to be suitable targets for passive immunotherapy with monoclonal antibodies and for active immunotherapy with vaccines. Studies aimed at further augmenting the effectiveness of these approaches are currently underway. © 1991 Academic Press Ltd. |
| Keywords: | review; molecular genetics; neoplasm; neoplasms; mouse; animal; metabolism; mice; melanoma; tumor antigen; monoclonal antibody; biosynthesis; immunology; antibodies, monoclonal; chemistry; molecular sequence data; antigen; immunotherapy; antigens; antigens, neoplasm; chemical structure; molecular structure; tumor vaccine; carbohydrate analysis; carbohydrate sequence; glycosphingolipid; gangliosides; ganglioside; human; support, non-u.s. gov't; ganglioside, gd3 |
| Journal Title: | Seminars in Cancer Biology |
| Volume: | 2 |
| Issue: | 6 |
| ISSN: | 1044-579X |
| Publisher: | Academic Press Inc., Elsevier Science |
| Date Published: | 1991-12-01 |
| Start Page: | 401 |
| End Page: | 409 |
| Language: | English |
| PUBMED: | 1810468 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
