Arm edema in conservatively managed breast cancer: Obesity is a major predictive factor Journal Article

  


Authors: Werner, R. S.; McCormick, B.; Petrek, J.; Cox, L.; Cirrincione, C.; Gray, J. R.; Yahalom, J.
Article Title: Arm edema in conservatively managed breast cancer: Obesity is a major predictive factor
Abstract: To identify risk factors in the development of arm edema (AE) after conservative management of breast cancer, the authors prospectively measured differences in upper and lower arm circumference in 282 patients with stage I or II breast cancer who received radiation. AE was defined as a difference of 2.5 cm or more in either measurement between treated and untreated arms. Median follow-up was 37 months (range, 7-109 months). The crude frequency of AE overall was 19.5% (55 patients). In 21 patients (7.4%) AE was transient; 34 patients (12.1%) had persistent AE, which is the focus of this article. The 5-year actuarial incidence of persistent AE was 16%. The crude risk of persistent severe AE was 3.9%. Various factors were examined for their ability to enable prediction of AE. Treatment-related factors did not significantly enable prediction of AE, whereas factors related to patient size, such as body mass index, were strongly associated with both the frequency and severity of AE.
Keywords: adult; aged; major clinical study; doxorubicin; fluorouracil; combined modality therapy; methotrexate; lymph node excision; prospective studies; edema; radiotherapy; risk factors; obesity; cyclophosphamide; radiation injury; breast neoplasms; body mass index; breast carcinoma; anthropometry; axilla; middle age; arm edema; arm; prognosis; human; female; priority journal; article; breast neoplasms, therapeutic radiology, 00.1299; extremities, abnormalities, 41.47,42.47; extremities, measurement, 41.1299,42.1299; lymphedema, 41.833, 42.833
Journal Title: Radiology
Volume: 180
Issue: 1
ISSN: 0033-8419
Publisher: Radiological Society of North America, Inc.  
Date Published: 1991-07-01
Start Page: 177
End Page: 184
Language: English
DOI: 10.1148/radiology.180.1.2052688
PUBMED: 2052688
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025797767&doi=10.1148%2fradiology.180.1.2052688&partnerID=40&md5=07e07f76baeea484107620b50f4ba659
Notes: Source: Scopus
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MSK Authors
  1. Joachim Yahalom
    625 Yahalom
  2. Jeanne Ann Petrek
    91 Petrek
  3. Beryl McCormick
    371 McCormick
  4. Louise Cox
    8 Cox
  5. Constance Cirrincione
    21 Cirrincione
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